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V.L. Tzounakas et al.
Intertwining biological networks in stored red blood cells and supernatants
In order to find out major aspects of bThal+ RBC phys- iology, able to interconnect the in vivo/ex vivo states, and thus, to reveal the “effect” (if any) of baseline variables
A
upon storage, we proceeded to comparative bThal+ versus control in vivo/ex vivo network analysis.
Our findings highlighted osmotic hemolysis as a “hub” parameter in bThal+ networks, with significant differ- ences in the type and the amount of connections between
B
C
Figure 6. Distinct metabolic pathways in beta thalassemia minor donors during storage II. (A) Arginine metabolism. (B) Vitamin B6 metabolism. (C) Hexosamine pathway. (D) Carnosine and indole-acetate. SAM: S-adenosyl methionine; ADMA: asymmetric dimethylarginine; *P<0.05, **P<0.01, #P<0.001, †P<0.0001.
D
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haematologica | 2022; 107(1)
