Page 107 - 2022_01-Haematologica-web

Early epigenetic changes in KM3-AML
for interactive gene ontology analysis. BMC
Bioinformatics. 2018;19(1):470.
48. Schaller MA, Kallal LE, Lukacs NW. A key
role for CC chemokine receptor 1 in T-cell- mediated respiratory inflammation. Am J Pathol. 2008;172(2):386-394.
49. Shin SY, Lee DH, Lee J, et al. C-C motif chemokine receptor 1 (CCR1) is a target of the EGF-AKT-mTOR-STAT3 signaling axis in breast cancer cells. Oncotarget. 2017;8 (55):94591-94605.
50.Kato T, Fujita Y, Nakane K, et al. CCR1/CCL5 interaction promotes invasion of taxane-resistant PC3 prostate cancer cells by increasing secretion of MMPs 2/9 and by activating ERK and Rac signaling. Cytokine. 2013;64(1):251-257.
51. Naya A, Sagara Y, Ohwaki K, et al. Design, synthesis, and discovery of a novel CCR1 antagonist. J Med Chem. 2001;44(9):1429- 1435.
52. Stunnenberg HG, International Human Epigenome Consortium, Hirst M. The International Human Epigenome Consortium: a blueprint for scientific collabo- ration and discovery. Cell. 2016;167(7): 1897.
53. Assi SA, Imperato MR, Coleman DJL, et al. Subtype-specific regulatory network rewiring in acute myeloid leukemia. Nat Genet. 2019;51(1):151-162.
54. Garcia-Cuellar MP, Buttner C, Bartenhagen C, Dugas M, Slany RK. Leukemogenic MLL- ENL fusions induce alternative chromatin states to drive a functionally dichotomous group of target genes. Cell Rep. 2016;15(2):
310-322.
55. Guenther MG, Lawton LN, Rozovskaia T, et
al. Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia. Genes Dev. 2008;22(24):3403- 3408.
56. Erfurth FE, Popovic R, Grembecka J, et al. MLL protects CpG clusters from methyla- tion within the Hoxa9 gene, maintaining transcript expression. Proc Natl Acad Sci U S A. 2008;105(21):7517-7522.
57. Alvarez S, Suela J, Valencia A, et al. DNA methylation profiles and their relationship with cytogenetic status in adult acute myeloid leukemia. PLoS One. 2010;5(8): e12197.
58. Zheng Y, Zhang H, Wang Y, et al. Loss of Dnmt3b accelerates MLL-AF9 leukemia pro- gression. Leukemia. 2016;30(12):2373-2384.
59. Schulze I, Rohde C, Scheller-Wendorff M, et al. Increased DNA methylation of Dnmt3b targets impairs leukemogenesis. Blood. 2016;127(12):1575-1586.
60.Trowbridge JJ, Sinha AU, Zhu N, et al. Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through dere- pression of bivalent chromatin domains. Genes Dev. 2012;26(4):344-349.
61. Hay SB, Ferchen K, Chetal K, Grimes HL, Salomonis N. The Human Cell Atlas bone marrow single-cell interactive web portal. Exp Hematol. 2018;68:51-61.
62. Cumbay MG, Watts VJ. Novel regulatory properties of human type 9 adenylate cyclase. J Pharmacol Exp Ther. 2004;310
(1):108-115.
63. Perez DR, Smagley Y, Garcia M, et al. Cyclic
AMP efflux inhibitors as potential therapeu- tic agents for leukemia. Oncotarget. 2016;7(23):33960-33982.
64. Gausdal G, Wergeland A, Skavland J, et al. Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis. Cell Death Dis. 2013;4(2):e516.
65. Bagger FO, Kinalis S, Rapin N. BloodSpot: a database of healthy and malignant haematopoiesis updated with purified and single cell mRNA sequencing profiles. Nucleic Acids Res. 2019;47(D1):D881-D885.
66. Gilliland CT, Salanga CL, Kawamura T, Trejo J, Handel TM. The chemokine recep- tor CCR1 is constitutively active, which leads to G protein-independent, beta- arrestin-mediated internalization. J Biol Chem. 2013;288(45):32194-32210.
67. Chen X, Burkhardt DB, Hartman AA, et al. MLL-AF9 initiates transformation from fast- proliferating myeloid progenitors. Nat Commun. 2019;10(1):5767.
68. Yan F, Powell DR, Curtis DJ, Wong NC. From reads to insight: a hitchhiker's guide to ATAC-seq data analysis. Genome Biol. 2020;21(1):22.
69. Borsari B, Villegas-Mirón P, Laayouni H, et al. Intronic enhancers regulate the expres- sion of genes involved in tissue-specific functions and homeostasis. bioRxiv. 2020 Aug 22. doi: 10.1101/2020.08.21.260836 [preprint, not peer-reviewed]
haematologica | 2022; 107(1)
99