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Letters to the Editor
act via MYB to elevate fetal hemoglobin expression in human trisomy
13. Proc Natl Acad Sci U S A. 2011;108(4):1519-1524.
6. Doroshow DB, Eder JP, LoRusso PM. BET inhibitors: a novel epigenetic
approach. Ann Oncol. 2017;28(8):1776-1787.
7. Stonestrom AJ, Hsu SC, Jahn KS, et al. Functions of BET proteins in ery-
throid gene expression. Blood. 2015;125(18):2825-2834.
8. Goupille O, Penglong T, Lefèvre C, et al. BET bromodomain inhibition rescues erythropoietin differentiation of human erythroleukemia cell line
UT7. Biochem Biophys Res Commun. 2012;429(1-2):1-5.
9. Zhou D, Liu K, Sun C-W, Pawlik KM, Townes TM. KLF1 regulates BCL11A expression and gamma- to beta-globin gene switching. Nat
Genet. 2010;42(9):742-744.
10. He Z, Russell JE. Expression, purification, and characterization of human
hemoglobins Gower-1 (zeta(2)epsilon(2)), Gower-2 (alpha(2)epsilon(2)), and Portland-2 (zeta(2)beta(2)) assembled in complex transgenic-knock- out mice. Blood. 2001;97(4):1099-1105.
11. Manning LR, Russell JE, Padovan JC, et al. Human embryonic, fetal, and adult hemoglobins have different subunit interface strengths. Correlation
with lifespan in the red cell. Protein Sci. 2007;16(8):1641-1658.
12. Russell JE, Liebhaber SA. Reversal of lethal alpha- and beta-thalassemias in mice by expression of human embryonic globins. Blood. 1998;
92(9):3057-3063.
13. He Z, Russell JE. A human embryonic hemoglobin inhibits Hb S poly-
merization in vitro and restores a normal phenotype to mouse models of
sickle cell disease. Proc Natl Acad Sci U S A. 2002;99(16):10635-10640. 14. Gordeuk VR, Campbell A, Rana S, et al. Relationship of erythropoietin, fetal hemoglobin, and hydroxyurea treatment to tricuspid regurgitation velocity in children with sickle cell disease. Blood. 2009;114(21):4639-
4644.
15. Ali MA, Ahmad A, Chaudry H, et al. Efficacy and safety of recently
approved drugs for sickle cell disease: a review of clinical trials. Exp
Hematol. 2020;92:11-18.e11.
16. Orkin SH, Bauer DE. Emerging genetic therapy for sickle cell disease.
Annu Rev Med. 2019;70:257-271.
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