Page 56 - 2021_06-Haematologica-web
P. 56
C. Zhang et al.
27. Park JE, Botting RA, Dominguez Conde C,
et al. A cell atlas of human thymic develop- ment defines T cell repertoire formation. Science. 2020;367(6480):eaay3224.
28. Kernfeld EM, Genga RMJ, Neherin K, et al. A single-cell transcriptomic atlas of thymus organogenesis resolves cell types and devel- opmental maturation. Immunity. 2018;48(6):1258-1270.e6.
29. Balkan W, Colbert M, Bock C, Linney E. Transgenic indicator mice for studying acti- vated retinoic acid receptors during devel- opment. Proc Natl Acad Sci U S A. 1992;89(8):3347-3351.
30. Arnold SL, Kent T, Hogarth CA, et al. Pharmacological inhibition of ALDH1A in mice decreases all-trans retinoic acid con- centrations in a tissue specific manner. Biochem Pharmacol. 2015;95(3):177-192.
31.Paik J, Haenisch M, Muller CH, et al. Inhibition of retinoic acid biosynthesis by the bisdichloroacetyldiamine WIN 18,446 markedly suppresses spermatogenesis and alters retinoid metabolism in mice. J Biol Chem. 2014;289(21):15104-15117.
32. Amory JK, Muller CH, Shimshoni JA, et al. Suppression of spermatogenesis by bis- dichloroacetyldiamines is mediated by inhibition of testicular retinoic acid biosyn- thesis. J Androl. 2011;32(1):111-119.
33. O'Neil J, Grim J, Strack P, et al. FBW7 muta- tions in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors. J Exp Med. 2007;204(8):1813-1824.
34. Herranz D, Ambesi-Impiombato A, Sudderth J, et al. Metabolic reprogramming
induces resistance to anti-NOTCH1 thera- pies in T cell acute lymphoblastic leukemia. Nat Med. 2015;21(10):1182-1189.
35. Kishton RJ, Barnes CE, Nichols AG, et al. AMPK is essential to balance glycolysis and mitochondrial metabolism to control T- ALL cell stress and survival. Cell Metab. 2016;23(4):649-662.
36. Singh S, Brocker C, Koppaka V, et al. Aldehyde dehydrogenases in cellular responses to oxidative/electrophilic stress. Free Radic Biol Med. 2013;56:89-101.
37. Sun X, Zhu H, Dong Z, et al. Mitochondrial aldehyde dehydrogenase-2 deficiency com- promises therapeutic effect of ALDH bright cell on peripheral ischemia. Redox Biol. 2017;13:196-206.
reactive oxygen species are essential for PI3K/Akt/mTOR-dependent IL-7-mediated viability of T-cell acute lymphoblastic leukemia cells. Leukemia. 2011;25(6):960- 967.
43.Giambra V, Jenkins CR, Wang H, et al. NOTCH1 promotes T cell leukemia-initiat- ing activity by RUNX-mediated regulation of PKC-θ and reactive oxygen species. Nat Med. 2012;18(11):1693-1698.
44. Hsieh AL, Walton ZE, Altman BJ, Stine ZE, Dang CV. MYC and metabolism on the path to cancer. Semin Cell Dev Biol. 2015;43:11-21.
45. Lien EC, Lyssiotis CA, Cantley LC. Metabolic reprogramming by the PI3K- Akt-mTOR pathway in cancer. Recent Results Cancer Res. 2016;207:39-72.
46. Anderson NM, Li D, Peng HL, et al. The TCA cycle transferase DLST is important for MYC-mediated leukemogenesis. Leukemia. 2016;30(6):1365-1374.
47. Seki M, Kimura S, Isobe T, et al. Recurrent SPI1 (PU.1) fusions in high-risk pediatric T cell acute lymphoblastic leukemia. Nat Genet. 2017;49(8):1274-1281.
48.Belver L, Ferrando A. The genetics and mechanisms of T cell acute lymphoblastic leukaemia. Nat Rev Cancer. 2016;16(8): 494-507.
49. Iacobucci I, Mullighan CG. Genetic basis of acute lymphoblastic leukemia. J Clin Oncol. 2017;35(9):975-983.
50. Langenau DM, Traver D, Ferrando AA, et al. Myc-induced T cell leukemia in trans- genic zebrafish. Science. 2003;299(5608): 887-890.
38. Kim J, Chen CH, Yang J, Mochly-Rosen D. Aldehyde dehydrogenase 2*2 knock-in mice show increased reactive oxygen species production in response to cisplatin treatment. J Biomed Sci. 2017;24(1):33.
39. Yang G, Ibuki Y. α,b-unsaturated aldehyde- induced delays in nucleotide excision repair and the contribution of reactive oxygen species. Chem Res Toxicol. 2018;31(2):145- 155.
40. Novitskiy G, Traore K, Wang L, Trush MA, Mezey E. Effects of ethanol and acetalde- hyde on reactive oxygen species produc- tion in rat hepatic stellate cells. Alcohol Clin Exp Res. 2006;30(8):1429-1435.
41.Tamura M, Ito H, Matsui H, Hyodo I. Acetaldehyde is an oxidative stressor for gastric epithelial cells. J Clin Biochem Nutr. 2014;55(1):26-31.
42. Silva A, Girio A, Cebola I, et al. Intracellular
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