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Letters to the Editor
A
Figure 1. The slope of estimated glomerular filtration rate (eGFR) decline in sickle cell anemia and the association of rapid eGFR decline with mortality in the pooled population are shown. (A) The change in eGFR over time, adjusted for baseline age, sex and main cohort effect, was -2.36 mL/min/1.73 m2 per year (95% Confidence Interval [CI]: -2.68 to-2.04; P<0.0001). (B) Kaplan-Meier estimates of the survival probabilities for rapid (>3.0 mL/min/1.73m2 per year) and non-rapid eGFR decline groups (log-rank test; P<0.0001). (C) Kaplan-Meier estimates of the survival proba-
B
C
bilities for
mL/min/1.73 m2 per year) and non-rapid eGFR decline groups (log-rank test; P<0.0001). The number of patients at risk at each time point are shown in (B ) and (C).
rapid (>5.0
haematologica | 2021; 106(6)