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Editorials
sub-populations of HSC. If so, the method of mobiliza- tion could have an impact on transplantation results. In breast cancer patients who need a transplant of autolo- gous MPB as part of their anticancer therapy, the trans- plantation of purified HSC improved the survival out- comes compared to those receiving non-purified MPB (https://doi.org/10.1016/j.bbmt.2011.07.009). It remains to be seen whether direct effects of G-CSF on HSC may influence transplantation outcomes.
In brief, the study by XIe et al. provides very interesting new data indicating that G-CSF can act directly on lym- phoid-biased but not on myeloid biased HSC. This find- ing may have implications for our understanding of immune responses, HSC aging, and bone marrow trans- plantation therapies.
Disclosures
No conflicts of interest to disclose.
Contributions
YC and KLR wrote the editorial together.
Acknowledgments
This work was funded by the German Research Foundation (DFG) within the CRC “PolyTarget” (SFB 1278, Project B01) and by the Federal Ministry of Research and Education (BMBF) within the HaematoOPT project (031A424D).
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