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Effect of G-CSF on mouse HSC
experiments; FD and QZ helped with the single-cell RT-PCR experiments; JW helped with the FACS operation; CW, CZ and PW helped with the PCR data analysis; SZ and BL helped with the culture experiments; HE designed and supervised the project and edited the manuscript.
Funding
This work was supported by grants from the National Key
Research and Development Program of China Stem Cell and Translational Research (2016YFA0100600, 2017YFA0104900, and 2019YFA0110203), CAMS Initiative for Innovative Medicine (CAMS-I2M) (2016-I2M-1-017 and 2017-I2M-1- 015), CAMS Fundamental Research Funds for Central Research Institutes (2019PT320017), and the National Natural Science Foundation of China (81670105, 81970119, 81670106, 81421002).
References
1. Till JE, McCulloch EA, Siminovitch L. A sto- chastic model of stem cell proliferation, based on the growth of spleen colony-form- ing cells. Proc Natl Acad Sci U S A. 1964; 51:29-36.
2. Bensinger W, Singer J, Appelbaum F, et al. Autologous transplantation with peripheral blood mononuclear cells collected after administration of recombinant granulocyte stimulating factor. Blood. 1993;81(11):3158- 3163.
3. Morrison SJ, Wright DE, Weissman IL. Cyclophosphamide/granulocyte colony- stimulating factor induces hematopoietic stem cells to proliferate prior to mobiliza- tion. Proc Natl Acad Sci U S A. 1997; 94(5):1908-1913.
4. Wright DE, Cheshier SH, Wagers AJ, Randall TD, Christensen JL, Weissman IL. Cyclophosphamide/granulocyte colony- stimulating factor causes selective mobiliza- tion of bone marrow hematopoietic stem cells into the blood after M phase of the cell cycle. Blood. 2001;97(8):2278-2285.
5. Wilson A, Laurenti E, Oser G, et al. Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell. 2008;135(6): 1118-1129.
6. Kovtonyuk LV, Manz MG, Takizawa H. Enhanced thrombopoietin but not G-CSF receptor stimulation induces self-renewing hematopoietic stem cell divisions in vivo. Blood. 2016;127(25):3175-3179.
7. Bernitz JM, Daniel MG, Fstkchyan YS, Moore K. Granulocyte colony-stimulating factor mobilizes dormant hematopoietic stem cells without proliferation in mice. Blood. 2017;129(14):1901-1912.
8. Petit I, Szyper-Kravitz M, Nagler A, et al. G- CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-reg- ulating CXCR4. Nat Immunol. 2002; 3(7):687-694.
9. Sugiyama T, Kohara H, Noda M, Nagasawa T. Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell nich- es. Immunity. 2006;25(6):977-988.
10. Abe T, Masuya M, Ogawa M. An efficient method for single hematopoietic stem cell engraftment in mice based on cell-cycle dor- mancy of hematopoietic stem cells. Exp Hematol. 2010;38(7):603-608.
11. Muller-Sieburg CE, Cho RH, Karlsson L, Huang JF, Sieburg HB. Myeloid-biased hematopoietic stem cells have extensive self-renewal capacity but generate dimin- ished lymphoid progeny with impaired IL-7 responsiveness. Blood. 2004;103(11):4111- 4118.
12. Muller-Sieburg CE, Cho RH, Thoman M, Adkins B, Sieburg HB. Deterministic regula- tion of hematopoietic stem cell self-renewal
and differentiation. Blood. 2002;100(4):
1302-1309.
13. Lieschke GJ, Grail D, Hodgson G, et al. Mice
lacking granulocyte colony-stimulating fac- tor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization. Blood. 1994;84(6):1737-1746.
14. Cohen AM, Zsebo KM, Inoue H, et al. In vivo stimulation of granulopoiesis by recombinant human granulocyte colony- stimulating factor. Proc Natl Acad Sci U S A. 1987;84(8):2484-2488.
15. Ieyasu A, Ishida R, Kimura T, et al. An all- recombinant protein-based culture system specifically identifies hematopoietic stem cell maintenance factors. Stem Cell Reports. 2017;8(3):500-508.
16. Wang X, Dong F, Zhang S, et al. TGF-beta1 negatively regulates the number and func- tion of hematopoietic stem cells. Stem Cell Reports. 2018;11(1):274-287.
17.Kent DG, Copley MR, Benz C, et al. Prospective isolation and molecular charac- terization of hematopoietic stem cells with durable self-renewal potential. Blood. 2009; 13(25):6342-6350.
18. Morita Y, Ema H, Nakauchi H. Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment. J Exp Med. 2010;207(6):1173- 1182.
19.Yamamoto R, Morita Y, Ooehara J, et al. Clonal analysis unveils self-renewing line- age-restricted progenitors generated directly from hematopoietic stem cells. Cell. 2013; 154(5):1112-1126.
20. Dong F, Bai H, Wang X, et al. Mouse acute leukemia develops independent of self- renewal and differentiation potentials in hematopoietic stem and progenitor cells. Blood Adv. 2019;3(3):419-431.
21. Wang J, Liu Z, Zhang S, et al. Lineage marker expression on mouse hematopoietic stem cells. Exp Hematol. 2019;76:13-23.e2.
22. Ema H, Morita Y, Suda T. Heterogeneity and hierarchy of hematopoietic stem cells. Exp Hematol. 2014;42(2):74-82.e2.
23. Alexander WS. Suppressors of cytokine sig- nalling (SOCS) in the immune system. Nat Rev Immunol. 2002;2(6):410-416.
24. Li S, Miao T, Sebastian M, et al. The tran- scription factors Egr2 and Egr3 are essential for the control of inflammation and antigen- induced proliferation of B and T cells. Immunity. 2012;37(4):685-696.
25. Gerdes J, Lemke H, Baisch H, Wacker HH, Schwab U, Stein H. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol. 1984;133(4):1710-1715.
26. Pietras EM, Warr MR, Passegue E. Cell cycle regulation in hematopoietic stem cells. J Cell Biol. 2011;195(5):709-720.
27. Barker JE. Sl/Sld hematopoietic progenitors are deficient in situ. Exp Hematol. 1994;22(2):174-177.
28. Chabot B, Stephenson DA, Chapman VM, Besmer P, Bernstein A. The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus. Nature. 1988;335(6185):88-89.
29. Ding L, Saunders TL, Enikolopov G, Morrison SJ. Endothelial and perivascular cells maintain haematopoietic stem cells. Nature. 2012;481(7382):457-462.
30. Matsumoto A, Takeishi S, Kanie T, et al. p57 is required for quiescence and maintenance of adult hematopoietic stem cells. Cell Stem Cell. 2011;9(3):262-271.
31. Zou P, Yoshihara H, Hosokawa K, et al. p57(Kip2) and p27(Kip1) cooperate to main- tain hematopoietic stem cell quiescence through interactions with Hsc70. Cell Stem Cell. 2011;9(3):247-261.
32. Qian H, Buza-Vidas N, Hyland CD, et al. Critical role of thrombopoietin in maintain- ing adult quiescent hematopoietic stem cells. Cell Stem Cell. 2007;1(6):671-684.
33. Kimura S, Roberts AW, Metcalf D, Alexander WS. Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin. Proc Natl Acad Sci U S A. 1998;95(3):1195-1200.
34. Wilkinson AC, Ishida R, Kikuchi M, et al. Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplan- tation. Nature. 2019;571(7763):117-121.
35. Kobayashi H, Morikawa T, Okinaga A, et al. Environmental optimization enables main- tenance of quiescent hematopoietic stem cells ex vivo. Cell Rep. 2019;28(1):145- 158.e9.
36.Kimura A, Kinjyo I, Matsumura Y, et al. SOCS3 is a physiological negative regulator for granulopoiesis and granulocyte colony- stimulating factor receptor signaling. J Biol Chem. 2004;279(8):6905-6910.
37. Croker BA, Metcalf D, Robb L, et al. SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granu- lopoiesis. Immunity. 2004;20(2):153-165.
38. Hirayama F, Shih JP, Awgulewitsch A, Warr GW, Clark SC, Ogawa M. Clonal prolifera- tion of murine lymphohemopoietic progen- itors in culture. Proc Natl Acad Sci U S A. 1992;89(13):5907-5911.
39. Nishinakamura R, Nakayama N, Hirabayashi Y, et al. Mice deficient for the IL-3/GM-CSF/IL-5 beta c receptor exhibit lung pathology and impaired immune response, while beta IL3 receptor-deficient mice are normal. Immunity. 1995;2(3):211- 222.
40. Hayashida K, Kitamura T, Gorman DM, Arai K, Yokota T, Miyajima A. Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony- stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor. Proc Natl Acad Sci U S A. 1990;87(24):9655-9659.
41. Ding L, Morrison SJ. Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches. Nature.
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