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Figure 1. Clonal evolution patterns associated with central nervous system relapse. PyClone analysis to retrace clonal phylogenies in five cases with document- ed central nervous system (CNS) dissemination. The leftmost column shows variant allele frequencies (VAF) at diagnosis vs. VAF in CNS sample. The middle column depicts clusters of mutation cellular prevalence. The rightmost column shows time sweep plots that graphically illustrated clonal tides over the course of relapse. Representative diffuse large B-cell lymphoma genes are labeled.
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