Page 172 - 2021_03-Haematologica-web
P. 172

J.V. Neves et al.
by combined intraperitoneal administration
of vitamins A and C to Trypanosoma brucei brucei-infected rats. Afr J Biotechnol. 2007; 6(18):2083-2086.
15. Clemens MR, Waller HD. Lipid peroxidation in erythrocytes. Chem Phys Lipids. 1987;45(2-4):251-268.
16.Szempruch AJ, Sykes SE, Kieft R, et al. Extracellular vesicles from Trypanosoma brucei mediate virulence factor transfer and cause host anemia. Cell. 2016;164(1-2):246- 257.
17. Stijlemans B, Beschin A, Magez S, Van Ginderachter JA, De Baetselier P. Iron home- ostasis and Trypanosoma brucei associated immunopathogenicity development: a bat- tle/quest for iron. Biomed Res Int. 2015;2015:819389.
18. Stijlemans B, Vankrunkelsven A, Brys L, Magez S, De Baetselier P. Role of iron home- ostasis in trypanosomiasis-associated ane- mia. Immunobiology. 2008;213(9-10):823- 835.
19.Nemeth E, Ganz T. Regulation of iron metabolism by hepcidin. Annu Rev Nutr. 2006;26:323-342.
20. Ganz T. Hepcidin-a regulator of intestinal iron absorption and iron recycling by macrophages. Best Pract Res Clin Haematol. 2005;18(2):171-182.
21. Ramey G, Deschemin JC, Durel B, Canonne- Hergaux F, Nicolas G, Vaulont S. Hepcidin targets ferroportin for degradation in hepato- cytes. Haematologica. 2010;95(3):501-504.
22. Moreira AC, Neves JV, Silva T, Oliveira P, Gomes MS, Rodrigues PN. Hepcidin- (in)dependent mechanisms of iron metabo- lism regulation during infection by Listeria and Salmonella. Infect Immun. 2017;85(9).
23.ArezesJ,JungG,GabayanV,etal.Hepcidin- induced hypoferremia is a critical host defense mechanism against the siderophilic bacterium Vibrio vulnificus. Cell Host Microbe. 2015;17(1):47-57.
24.Burns M, Muthupalani S, Ge Z, et al. Helicobacter pylori infection induces ane- mia, depletes serum iron storage, and alters local iron-related and adult brain gene expression in male INS-GAS mice. PLoS One. 2015;10(11):e0142630.
25.Kim A, Fung E, Parikh SG, et al. A mouse model of anemia of inflammation: complex pathogenesis with partial dependence on hepcidin. Blood. 2014;123(8):1129-1136.
26.Gardenghi S, Renaud TM, Meloni A, et al. Distinct roles for hepcidin and interleukin-6 in the recovery from anemia in mice injected with heat-killed Brucella abortus. Blood. 2014;123(8):1137-1145.
27. Ben-Othman R, Flannery AR, Miguel DC, Ward DM, Kaplan J, Andrews NW. Leishmania-mediated inhibition of iron export promotes parasite replication in macrophages. PLoS Pathog. 2014;10(1) :e1003901.
28. Ferrer P, Castillo-Neyra R, Roy CN, Sullivan DJ Jr. Dynamic control of hepatic Plasmodium numbers by hepcidin despite elevated liver iron during iron supplementa- tion. Microbes Infect. 2016;18(1):48-56.
29. Lesbordes-Brion JC, Viatte L, Bennoun M, et al. Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis. Blood. 2006;108(4):1402-1405.
30. Torrence JD, Bothwell TH. Tissue Iron Stores. In: Cook JD, editor. Methods in haematology. New York: Churchill Livingston Press; 1980. p. 104-9.
31. McLatchie AP, Burrell-Saward H, Myburgh E, et al. Highly sensitive in vivo imaging of Trypanosoma brucei expressing "red-shift- ed" luciferase. PLoS Negl Trop Dis. 2013;7(11):e2571.
32. Viatte L, Vaulont S. Hepcidin, the iron watch- er. Biochimie. 2009;91(10):1223-1228.
33. Wang W, Knovich MA, Coffman LG, Torti FM, Torti SV. Serum ferritin: past, present and future. Biochim Biophys Acta. 2010; 1800(8):760-769.
34. Basu S, Horakova E, Lukes J. Iron-associated biology of Trypanosoma brucei. Biochim Biophys Acta. 2016;1860(2):363-370.
35.Stefanova D, Raychev A, Arezes J, et al. Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non-transferrin-bound iron. Blood. 2017; 130(3):245-257.
36.Stefanova D, Raychev A, Deville J, et al. Hepcidin protects against lethal Escherichia coli sepsis in mice inoculated with isolates from septic patients. Infect Immun. 2018; 86(7).
37.Andrews NC. Anemia of inflammation: the cytokine-hepcidin link. J Clin Invest. 2004; 113(9):1251-1253.
38. Roy CN, Andrews NC. Anemia of inflam- mation: the hepcidin link. Curr Opin Hematol. 2005;12(2):107-111.
39. Soares MP, Hamza I. Macrophages and iron metabolism. Immunity. 2016;44(3):492-504.
40. Nemeth E, Rivera S, Gabayan V, et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest. 2004; 113(9):1271-1276.
41. Wrighting DM, Andrews NC. Interleukin-6 induces hepcidin expression through STAT3. Blood. 2006;108(9):3204-3209.
42.Felli N, Pedini F, Zeuner A, et al. Multiple members of the TNF superfamily contribute to IFN-gamma-mediated inhibition of ery- thropoiesis. J Immunol. 2005;175(3):1464- 1472.
43. Magez S, Radwanska M, Beschin A, Sekikawa K, De Baetselier P. Tumor necrosis factor alpha is a key mediator in the regulation of experimental Trypanosoma brucei infec- tions. Infect Immun. 1999;67(6):3128-3132.
44. Magez S, Schwegmann A, Atkinson R, et al. The role of B-cells and IgM antibodies in par- asitemia, anemia, and VSG switching in Trypanosoma brucei-infected mice. PLoS Pathog. 2008;4(8):e1000122.
45. Deshmane SL, Kremlev S, Amini S, Sawaya BE. Monocyte chemoattractant protein-1 (MCP-1): an overview. J Interferon Cytokine Res. 2009;29(6):313-326.
46. Leon B, Lopez-Bravo M, Ardavin C. Monocyte-derived dendritic cells formed at the infection site control the induction of
protective T helper 1 responses against
Leishmania. Immunity. 2007;26(4):519-531. 47. Dunay IR, Damatta RA, Fux B, et al. Gr1(+) inflammatory monocytes are required for mucosal resistance to the pathogen Toxoplasma gondii. Immunity. 2008;
29(2):306-317.
48. Sponaas AM, Freitas do Rosario AP, Voisine
C, et al. Migrating monocytes recruited to the spleen play an important role in control of blood stage malaria. Blood. 2009; 114(27):5522-5531.
49. Bosschaerts T, Guilliams M, Stijlemans B, et al. Tip-DC development during parasitic infection is regulated by IL-10 and requires CCL2/CCR2, IFN-gamma and MyD88 sig- naling. PLoS Pathog. 2010;6(8):e1001045.
50. Liu Y, Li Z, Bakhiet M. Upregulation of the chemokines Rantes, MCP-1, MIP-1a and MIP-2 in early infection with Trypanosoma brucei brucei and inhibition by sympathetic denervation of the spleen. Trop Med Int Health. 1999;4(2):85-92.
51. Guilliams M, Movahedi K, Bosschaerts T, et al. IL-10 dampens TNF/inducible nitric oxide synthase-producing dendritic cell-mediated pathogenicity during parasitic infection. J Immunol. 2009;182(2):1107-1118.
52.
Musaya J, Matovu E, Nyirenda M, Chisi J. Role of cytokines in Trypanosoma brucei- induced anaemia: a review of the literature. Malawi Med J. 2015;27(2):45-50.
53. Rishi G, Wallace DF, Subramaniam VN. Hepcidin: regulation of the master iron regu- lator. Biosci Rep. 2015;35(3).
54. Deschemin JC, Vaulont S. Role of hepcidin in the setting of hypoferremia during acute inflammation. PLoS One. 2013;8(4):e61050.
55. Willemetz A, Beatty S, Richer E, et al. Iron- and hepcidin-independent downregulation of the iron exporter ferroportin in macrophages during Salmonella infection. Front Immunol. 2017;8:498.
56.Nemeth E, Tuttle MS, Powelson J, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its inter- nalization. Science. 2004;306(5704):2090- 2093.
57.Kautz L, Jung G, Valore EV, Rivella S, Nemeth E, Ganz T. Identification of erythro- ferrone as an erythroid regulator of iron metabolism. Nat Genet. 2014;46(7):678-684.
58.Arezes J, Foy N, McHugh K, et al. Erythroferrone inhibits the induction of hep- cidin by BMP6. Blood. 2018;132(14):1473- 1477.
59. Kautz L, Jung G, Nemeth E, Ganz T. Erythroferrone contributes to recovery from anemia of inflammation. Blood. 2014; 124(16):2569-2574.
60. Tanno T, Bhanu NV, Oneal PA, et al. High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat Med. 2007;13(9):1096-1101.
61.Tanno T, Porayette P, Sripichai O, et al. Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells. Blood. 2009; 114(1):181-186.
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