Page 109 - 2021_02-Haematologica-web

MicroRNA-21 maintains HSC homeostasis
P, et al. Cohesin loss alters adult hematopoi- etic stem cell homeostasis, leading to myelo- proliferative neoplasms. J Exp Med. 2015;212(11):1833-1850.
32. Fang J, Muto T, Kleppe M, et al. TRAF6 mediates basal activation of NF-κB neces- sary for hematopoietic stem cell homeo- stasis. Cell Rep. 2018;22(5):1250-1262.
33. Shi C, Yang Y, Xia Y, et al. Novel evidence for an oncogenic role of microRNA-21 in colitis-associated colorectal cancer. Gut. 2016;65(9):1470-1481.
34. Wang X, Zhang L, Wei Z, et al. The inhibito- ry action of PDCD4 in lipopolysaccharide/ D-galactosamine-induced acute liver injury. Lab Invest. 2013;93(3):291-302.
radioprotective activity in mouse and primate
models. Science. 2008;320(5873):226-230. 38. de Laval B, Pawlikowska P, Barbieri D, et al. Thrombopoietin promotes NHEJ DNA repair in hematopoietic stem cells through specific activation of Erk and NF-κB path- ways and their target, IEX-1. Blood.
2014;123(4):509-519.
39. Krichevsky AM, Gabriely G. miR-21: a small
multi-faceted RNA. J Cell Mol Med.
2009;13(1):39-53.
40. Liu K, Du J, Ruan L. MicroRNA-21 regulates
the viability and apoptosis of diffuse large B- cell lymphoma cells by upregulating B cell lymphoma-2. Exp Ther Med. 2017;14(5): 4489-4496.
41. Zhao C, Xiu Y, Ashton J, et al. Noncanonical NF-κB signaling regulates hematopoietic stem cell self-renewal and microenviron- ment interactions. Stem Cells. 2012;30(4): 709-718.
42. Nakagawa MM, Rathinam CV. Constitutive Activation of the canonical NF-κB pathway leads to bone marrow failure and induction of erythroid signature in hematopoietic stem cells. Cell Rep. 2018;25 (8):2094-2109 e2094.
43. Zhang Z, Zha Y, Hu W, et al. The autoregu- latory feedback loop of microRNA-21/pro- grammed cell death protein 4/activation protein-1 (MiR-21/PDCD4/AP-1) as a driv-
ing force for hepatic fibrosis development. J
Biol Chem. 2013;288(52):37082-37093.
44. Sheedy FJ, Palsson-McDermott E, Hennessy EJ, et al. Negative regulation of TLR4 via tar- geting of the proinflammatory tumor sup- pressor PDCD4 by the microRNA miR-21.
Nat Immunol. 2010;11(2):141-147.
45. Ma X, Becker Buscaglia LE, Barker JR, Li Y. MicroRNAs in NF-kappaB signaling. J Mol
Cell Biol. 2011;3(3):159-166.
46. Xu G, Wu H, Zhang J, et al. Metformin ame-
liorates ionizing irradiation-induced long- term hematopoietic stem cell injury in mice. Free Radic Biol Med. 2015;87:15-25.
47. Hu B, Wang X, Hu S, et al. miR-21-mediated Radioresistance occurs via promoting repair of DNA double strand breaks. J Biol Chem. 2017;292(8):3531-3540.
48. Zhang X, Wan G, Berger FG, He X, Lu X. The ATM kinase induces microRNA biogen- esis in the DNA damage response. Mol Cell. 2011;41(4):371-383.
49. Zhu Y, Yu X, Fu H, et al. MicroRNA-21 is involved in ionizing radiation-promoted liver carcinogenesis. Int J Clin Exp Med. 2010;3(3):211-222.
50. Puccetti MV, Adams CM, Dan TD, et al. MicroRNA-21 is required for hematopoietic cell viability after radiation exposure. Int J Radiat Oncol Biol Phys. 2019;104(5):1165- 1174.
35. Mao XH, Chen M, Wang Y, Cui PG, Liu SB, Xu ZY. MicroRNA-21 regulates the ERK/NF- κB signaling pathway to affect the prolifera- tion, migration, and apoptosis of human melanoma A375 cells by targeting SPRY1, PDCD4, and PTEN. Mol Carcinog. 2017;56(3):886-894.
36. Kraft D, Rall M, Volcic M, et al. NF-κB- dependent DNA damage-signaling differen- tially regulates DNA double-strand break repair mechanisms in immature and mature human hematopoietic cells. Leukemia. 2015;29(7):1543-1554.
37. Burdelya LG, Krivokrysenko VI, Tallant TC, et al. An agonist of toll-like receptor 5 has
haematologica | 2021; 106(2)
423