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Y. Zhou et al.
pared to migfilin, changes of filamin A has far more exten- sive impact on megakaryocytes and platelets.6,37
In conclusion, migfilin is an important positive regulator for hemostasis and thrombosis. Through regulating the binding dynamics of filamin A and aIIbβ3 (Figure 6), migfilin promotes early outside-in signaling of aIIbβ3 and supports platelet dense granule secretion. Further studies of migfilin will possibly lead to the discovery of new reg-
ulators important for platelet function and effective man- agement of thrombosis.
Funding
This study was supported by grants from National Natural Science Foundation of China (81670131 and 81870106), Zhejiang Provincial Natural Science Foundation (LZ18H080001).
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