Page 71 - 2020_09-Haematologica-web
P. 71
XPO1 is a target to treat β-thalassemia
tifies cell-type-specific regulators of H3K27me3 patterns. Proc Natl Acad Sci U S A. 2014;111(3):344-353.
15. Etchin J, Sun Q, Kentsis A, et al. Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells. Leukemia. 2013;27(1):66-74.
16. Lapalombella R, Sun Q, Williams K, et al. Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia. Blood. 2012; 120(23): 4621-4634.
17. Etchin J, Sanda T, Mansour MR, et al. KPT- 330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia. Br J Haematol. 2013;161(1):117-127.
18. Kojima K, Kornblau SM, Ruvolo V, et al. Prognostic impact and targeting of CRM1
in acute myeloid leukemia. Blood. 2013;
121(20):4166-4174.
19. Walker CJ, Oaks JJ, Santhanam R, et al.
Preclinical and clinical efficacy of XPO1/CRM1 inhibition by the karyo- pherin inhibitor KPT-330 in Ph+ leukemias. Blood. 2013;122(17):3034-3044.
20. Wettersten HI, Landesman Y, Friedlander S, Shacham S, Kauffman M, Weiss RH. Specific inhibition of the nuclear exporter exportin-1 attenuates kidney cancer growth. PloS One. 2014;9(12):1-15.
21. Ranganathan P, Yu X, Na C, et al. Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia. Blood. 2012;120(9):1765-1773.
22. Gravina GL, Mancini A, Sanita P, et al. KPT-330, a potent and selective exportin-1 (XPO-1) inhibitor, shows antitumor effects modulating the expression of cyclin D1 and survivin [corrected] in prostate cancer
models. BMC Cancer. 2015;15:941-960. 23. Tai Y-T, Landesman Y, Acharya C, et al. CRM1 inhibition induces tumor cell cyto- toxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications. Leukemia.
2014;28(1):155-165.
24. Zeng X-C, Bhasin S, Wu X, et al. Hsp70
dynamics in vivo: effect of heat shock and protein aggregation. J Cell Sci. 2004;117(Pt 21):4991-5000.
25. Frisan E, Vandekerckhove J, de Thonel A, et al. Defective nuclear localization of Hsp70 is associated with dyserythro- poiesis and GATA-1 cleavage in myelodys- plastic syndromes. Blood. 2012;119(6): 1532-1542.
26. Gastou M, Rio S, Dussiot M, et al. The severe phenotype of Diamond-Blackfan anemia is modulated by heat shock protein 70. Blood Adv. 2017;1(22):1959-1976.
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