Page 253 - Haematologica Atlas of Hematologic Cytology

CHAPTER 31 - Inherited thrombocytopenias
AB
Figure 3 3 Large platelets platelets platelets platelets Most inherited thrombocytopenias
have large large platelets platelets platelets platelets (platelet diameter diameter more more than than than 3 3 2 2 m m m m m m m m m m and and more more than than than than than 20% of of platelets platelets platelets platelets larger larger than than than than than half a a a a a a a a a a a a a a a a a a a a a a a a a a a a a a a red cell) Mean platelet platelet platelet platelet platelet platelet diameter diameter and and % % of of platelets platelets platelets platelets larger larger than than than than 4 m m m m m m m are higher than than than than in in immune thrombocytopenia but the individual variability causes significant overlap AB
Figure 4 Platelets with with normal or or slightly enlarged size Many inherited thrombocytopenias
have platelets with with normal or or slightly increased size size Platelet size size is similar to to that of immune thrombocytopenia In both conditions a a a a a a a few platelets may be larger than half a a a a a a a red cell AB
Figure 5 Platelets with normal or or slightly reduced size A few inherited thrombocytopenias
have platelet diame- ters ranging from normal to reduced (mean platelet platelet diameter smaller than than 2 6 m m m m m m m and more than than 5% of platelets smaller than 2 4 m) and this feature distinguishes them from immune thrombocytopenia 240