Page 153 - Haematologica Atlas of Hematologic Cytology

CHAPTER 17 - - Mature B-cell neoplasms
Mantle cell lymphoma Leukemic non-nodal mantle cell lymphoma In situ mantle cell neoplasia
Diffuse large large B-cell B-cell lymphoma lymphoma not otherwise specified (NOS)
T-cell/histiocyte-rich large large large B-cell B-cell B-cell lymphoma lymphoma lymphoma Primary Primary diffuse diffuse large large large B-cell B-cell B-cell lymphoma lymphoma lymphoma of the central nervous system (CNS) Primary Primary cutaneous diffuse diffuse diffuse large large large B-cell B-cell B-cell lymphoma lymphoma lymphoma leg type Epstein-Barr virus (EBV)-positive diffuse diffuse large large B-cell B-cell lymphoma lymphoma NOS EBV-positive mucocutaneous ulcer
Diffuse large large B-cell B-cell lymphoma lymphoma associated associated with chronic inflammation
Fibrin-associated diffuse large B-cell lymphoma Lymphomatoid granulomatosis
Primary mediastinal (thymic) large large B-cell B-cell lymphoma lymphoma Intravascular large large large B-cell B-cell B-cell lymphoma lymphoma ALK-positive large large B-cell B-cell lymphoma lymphoma lymphoma Plasmablastic lymphoma lymphoma lymphoma Primary effusion lymphoma lymphoma HHV8-associated lymphoproliferative disorders Multicentric Castleman disease HHV8-positive diffuse large B-cell lymphoma NOS* HHV8-positive germinotropic lymphoproliferative disorder Burkitt Burkitt lymphoma lymphoma Burkitt-like lymphoma lymphoma lymphoma with 11q aberration High-grade High-grade B-cell B-cell lymphoma lymphoma lymphoma High-grade B-cell lymphoma with MYC and and BCL2 and/or BCL6 rearrangements
High-grade B-cell lymphoma NOS B-cell B-cell B-cell lymphoma lymphoma lymphoma lymphoma unclassifiable with features intermediate between diffuse large B-cell B-cell B-cell lymphoma lymphoma lymphoma lymphoma and classic Hodgkin lymphoma *Provisional entity POEMS: Polyneuropathy Organomegaly Endocrinopathy Monoclonal Monoclonal gammopathy gammopathy Skin changes TEMPI: Telangiectasias Elevated erythropoietin and erythrocytosis Monoclonal Monoclonal gammopathy gammopathy Peri- pheral fluid collection Intrapulmonary shunting
Table 2 Cytological features of mature B-cell lymphoid leukemias Cell
Size
hroma n Nucleolus
Cytoplasm
Other features Small lymphocyte
<2 RBCs
Coarsely clumped
Absent
Scanty
Prolymphocyte
>2 RBCs
Clumped
One prominent
Abundant
Hairy cell >2 RBCs
Rather loose
Absent
or small Abundant
Cytoplasmic villi
Lymphoplasmacyte
>2 RBCs
Clumped
Absent
Abundant
basophilic
Eccentric nucleus
Plasma cell >2 RBCs
Coarsely clumped
Absent
Abundant
basophilic
Eccentric nucleus
Centrocyte
<2 RBCs
Clumped
homogeneous
Absent
Very scanty
1-2 nuclear indenta ons Centroblast
>2 RBCs
Loose
Mul ple peripheral Scanty
Immunoblast
>2 RBCs
Rather clumped
One evident
Abundant
basophilic
ur i cell >2 RBCs
Finely clumped
Mul ple paracentral
Abundant
basophilic
Cytoplasmic lipid vacuoles
RBCs: red blood cells 140