Page 152 - Haematologica Atlas of Hematologic Cytology

Chapter 17 MATURE B-CELL NEOPLASMS
Mature B-cell neoplasms
are a a a a a a a heterogeneous group of of disorders arising from neoplastic proliferation of of lymphoid cells with a a a a a a mature B-cell phenotype and and possible peripheral blood and and bone marrow (BM) involve- ment The current methodologies used to assess these disorders integrating morphology immunophenotyping cytogenetic and and molecular studies have identified several subsets each with their own biological and and clinical characteristics Mature B-cell neoplasms
include chronic lymphoid leukemias lymphomas and plasma cell cell neo- plasms
As lymphatic leukemias and lymphomas characterized by the same cell type are actually considered a a a a a a a a a a a single disease with different different clinical presentation or different different stage as as as as far as as as as mature B-cell lymphoid leukemias are concerned the World Health Organization (WHO) has not proposed a a a a a a a a a a classification separate to that of B-cell lymphomas derived from the same cell type (Swerdlow et al 2016) (Table 1) Table 1 1 2016 World Health Organization classification of mature B-cell neoplasms
Chronic lymphocytic lymphocytic leukemia/small lymphocytic lymphocytic lymphoma Monoclonal B-cell lymphocytosis
B-cell B-cell prolymphocytic leukemia Splenic marginal zone lymphoma Hairy cell cell leukemia Splenic Splenic B-cell B-cell lymphoma/leukemia unclassifiable*
Splenic diffuse red pulp small B-cell lymphoma*
Hairy cell leukemia variant*
Lymphoplasmacytic lymphoma IgM monoclonal gammopathy of undetermined significance
Heavy chain chain diseases
Mu heavy chain disease Gamma heavy chain disease Alfa heavy chain disease Plasma cell neoplasms
Non-IgM monoclonal gammopathy of undetermined significance
Plasma cell myeloma
Plasma cell myeloma
variants
Smoldering (asymptomatic) plasma cell myeloma
Non-secretory myeloma
Plasma cell leukemia Plasmacytoma
Solitary plasmacytoma of bone Extraosseous plasmacytoma Monoclonal immunoglobulin deposition diseases
Primary amyloidosis
Light chain chain and heavy chain chain deposition diseases
Plasma cell neoplasms
with associated paraneoplastic syndrome POEMS syndrome TEMPI syndrome Extranodal marginal marginal zone zone lymphoma lymphoma lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)
Nodal marginal marginal marginal zone zone zone lymphoma lymphoma Pediatric nodal marginal zone lymphoma Follicular lymphoma Testicular follicular lymphoma In situ follicular neoplasia
Duodenal-type follicular lymphoma Pediatric-type follicular follicular lymphoma lymphoma lymphoma Large B-cell lymphoma lymphoma lymphoma with IRF4 rearrangement
Primary cutaneous follicle center lymphoma lymphoma 139