Page 128 - Haematologica Atlas of Hematologic Cytology

Figure 0 cute monocy c c c leu emia Bone marrow smear from an an 18-year-old man presen ng with with severe anemia mild thrombocytopenia and normal white blood cell count with with 40% blasts Leukemic popula on on on on shows evident monocy c c c c di di eren a a a a a on: in addi on on on on to blast cells there are many promonocytes and monocytes monocytes Note the hemophagocytosis in two cells The diagnosis of acute monocy c c c c c c leukemia was con rmed by cytochemistry and immunophenotyping AB
Figure Figure 1 cute monocy c c c c leu emia Bone marrow smear from the same case as as Figure Figure 30 ( and ) Evident erytrophagocytosis in in blasts Chromosomal analysis revealed t(8 16)(p11 2 p13 3) in in a a a a a a a a a a high percentage of metapha- ses ses This abnormality may occur in in acute monocy monocy c c c c c c c c c or or myelomonocy c c c c c c c c c leukemia and in in most cases is is associated with coagulopathy and hemophagocytosis especially erythrophagocytosis by leukemic cells Erythrophagocytosis is generally responsible for a a a a very severe anemia 115