Page 76 - Haematologica Vol. 110 - January 2025

ARTICLE - Acute Myeloid Leukemia
Hematopoietic cell transplantation for older acute myeloid leukemia patients in first complete remission: results of a randomized phase III study
Dietger Niederwieser,1,2,3 Dirk Hasenclever,4 Wolfgang E. Berdel,5 Bart J. Biemond,6 Haifa Al-Ali,7 Yves Chalandon,8,9 Michel van Gelder,10 Christian Junghanß,11 Gösta Gahrton,12 Mathias Hänel,13 Rüdiger Hehlmann,14 Thomas Heinicke,15 Andreas Hochhaus,16 Simona Iacobelli,17 Rien van Marwijk Kooy,18 Nicolaus Kröger,19 Jeroen Janssen,20 Madlen Jentzsch,21 Frank Breywisch,22 Mohamad Mohty,23 Stavroula Masouridi-Levrat,9,24 Gert Ossenkoppele,25 Jacob Passweg,9,26 Wolfram Pönisch,27 Johannes Schetelig,28 Christoph Schliemann,29 Sebastian Schwind,30 Matthias Stelljes,31 Leo F. Verdonck,32 Vladan Vucinic,33 Bob Löwenberg,34# and Jan Cornelissen34#
1University Leipzig, Leipzig, Germany; 2Aichi Medical University School of Medicine, Nagakute, Japan; 3KaunoKlinikos University of Health Sciences, Kaunas, Lithuania; 4Institute for Medical Informatics, Statistics and Epidemiology (IMISE) ) in cooperation with the Clinical Trial Center (ZKS), University of Leipzig, Leipzig, Germany; 5Universitätsklinikum, Münster, Germany; 6Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; 7University Hospital, Halle, Germany; 8Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland; 9Swiss Group for Clinical Cancer Research (SAKK), Bern, Switzerland; 10Maastricht University Medical Center, Maastricht, the Netherlands; 11Universitätsklinikum Rostock, Rostock, Germany; 12Department of Medicine, Karolinska Institute, Stockholm, Sweden; 13Klinikum Chemnitz GmbH, Chemnitz, Germany; 14Medizinische Fakultät Mannheim, Universität Heidelberg, and European Leukemia Net Foundation, Weinheim, Germany; 15Department of Hematology and Oncology, Otto-von- Guericke University, Magdeburg, Germany; 16Universitätsklinikum Jena, Jena, Germany; 17Università di Roma “Tor Vergata”, Dipartimento di Biologia, Roma, Italy; 18Isala Clinic Zwolle, Zwolle, the Netherlands; 19University Medical Center Hamburg, Hamburg, Germany; 20Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; 21University of Leipzig, Leipzig, Germany; 22Department of Hematology, Oncology and Palliative Care, Ernst Von Bergmann Hospital, Potsdam, Germany; 23Sorbonne University, Hospital Saint Antoine Department of Hematology, INSERM UMRS 938, Paris, France; 24Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland; 25VU University Medical Center, Amsterdam, the Netherlands; 26Klinik für Hämatologie, Universitätsspital Basel, Basel, Switzerland; 27University Leipzig, Leipzig, Germany; 28University Hospital, TU Dresden, Dresden, Germany; 29University Hospital Münster, Department of Medicine A, Münster, Germany; 30University of Leipzig, Leipzig, Germany; 31University Hospital Münster, Department of Medicine A, Münster, Germany; 32Isala Clinic Zwolle, Zwolle, the Netherlands; 33University of Leipzig, Leibzig, Germany and 34Erasmus University Medical Center Rotterdam and Erasmus MC Cancer Institute, Rotterdam, the Netherlands
#BL and JC contributed equally as senior authors. Abstract
Given the selection of elderly patients with AML in first complete remission (CR1) the advantage of consolidation with allo- geneic hematopoietic cell transplantation (HCT) over chemotherapy is still unclear. Newly diagnosed AML patients in CR1 aged 60-75 years were registered and a donor search initiated. After one consolidation cycle, patients with a matched donor were randomized to HCT with fludarabine/low-dose total body irradiation and cyclosporine/mycophenolate mofetil immu- nosuppression or conventional non-HCT. Primary outcome was restricted mean leukemia-free survival (RM-LFS) up to 5
Haematologica | 110 January 2025
Correspondence: D. Niederwieser dietger@medizin.uni-leipzig.de
Received: Accepted: Early view:
May 17, 2024. August 1, 2024. August 8, 2024.
https://doi.org/10.3324/haematol.2024.285879
©2025 Ferrata Storti Foundation Published under a CC BY-NC license
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