Page 118 - Haematologica Vol. 110 - January 2025
P. 118
ARTICLE - LIPA modulates venetoclax/TKI response in bpCML M. Minhajuddin et al. AB
C
DE
FG
Figure 5. Upregulation of genes related to lysosome biology protects leukemia stem cells from venetoclax/dasatinib combination therapy. (A) Experimental design for treatment, flow sorting, and RNA isolation from leukemia stem cells (LSC) for total RNA se- quencing. (B) Principal component analysis plot for gene expression profile in groups treated with vehicle, dasatinib, and the
Haematologica | 110 January 2025
110
Continued on following page.
