Page 89 - Haematologica-5

haematologica | 2018; 103(5)
Zhang N, Coombes KR. Highly phosphory- lated FOXO3A is an adverse prognostic fac- tor in acute myeloid leukemia. Clin Cancer Res. 2010;16(6):1865-1874.
29. Kornblau SM, Womble M, Qiu YH, et al. Simultaneous activation of multiple signal transduction pathways confers poor prog- nosis in acute myelogenous leukemia. Blood. 2006;108(7):2358-2365.
30. Ruvolo PP, Qiu Y, Coombes KR, et al. Phosphorylation of GSK3alpha/beta corre- lates with activation of AKT and is prognos- tic for poor overall survival in acute myeloid leukemia patients. BBA Clin. 2015;4:59-68.
31. Ruvolo PP, Qui YH, Coombes KR, et al. Low expression of PP2A regulatory subunit B55alpha is associated with T308 phospho- rylation of AKT and shorter complete remis- sion duration in acute myeloid leukemia patients. Leukemia. 2011; 25(11):1711-1717.
32. Tibes R, Qiu Y, Lu Y, et al. Reverse phase protein array: validation of a novel proteom- ic technology and utility for analysis of pri- mary leukemia specimens and hematopoiet- ic stem cells. Mol Cancer Ther. 2006;5(10):2512-2521.
33. Szklarczyk D, Franceschini A, Wyder S, et al. STRING v10: protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res. 2015;43(Database issue):D447-452.
34. Huang JC, Basu SK, Zhao X, et al. Mesenchymal stromal cells derived from acute myeloid leukemia bone marrow exhibit aberrant cytogenetics and cytokine elaboration. Blood Cancer J. 2015;5:e302.
35. Bertrand J, Despeaux M, Joly S, et al. Sex dif- ferences in the GSK3beta-mediated survival of adherent leukemic progenitors. Oncogene. 2012;31(6):694-705.
36. Blalock WL, Piazzi M, Bavelloni A, et al.
43. Gharibi B, Ghuman MS, Hughes FJ. Akt- and Erk-mediated regulation of proliferation and differentiation during PDGFRbeta- induced MSC self-renewal. J Cell Mol Med. 2012;16(11):2789-2801.
44. Lai VK, Ashraf M, Jiang S, Haider K. MicroRNA-143 is a critical regulator of cell cycle activity in stem cells with co-overex- pression of Akt and angiopoietin-1 via tran- scriptional regulation of Erk5/cyclin D1 sig- naling. Cell Cycle. 2012;11(4):767-777.
Proteomic profiling reveals complexity of AML MSC
chemoresistance. Blood. 2014;123(17):2691-
2702.
8. Studeny M, Marini FC, Dembinski JL, et al.
Mesenchymal stem cells: potential precur- sors for tumor stroma and targeted-delivery vehicles for anticancer agents. J Natl Cancer Inst. 2004;96(21):1593-1603.
9. Battula VL, Chen Y, Cabreira Mda G, et al. Connective tissue growth factor regulates adipocyte differentiation of mesenchymal stromal cells and facilitates leukemia bone marrow engraftment. Blood. 2013; 122(3): 357-366.
10. Chen Y, Jacamo R, Shi YX, et al. Human extramedullary bone marrow in mice: a novel in vivo model of genetically controlled hematopoietic microenvironment. Blood. 2012;119(21):4971-4980.
11. Kidd S, Spaeth E, Watson K, et al. Origins of the tumor microenvironment: quantitative assessment of adipose-derived and bone marrow-derived stroma. PLoS One. 2012;7(2):e30563.
12. Ling X, Marini F, Konopleva M, et al. Mesenchymal Stem Cells Overexpressing IFN-beta Inhibit Breast Cancer Growth and Metastases through Stat3 Signaling in a Syngeneic Tumor Model. Cancer Microenviron. 2010;3(1):83-95.
13. Poggi A, Giuliani M. Mesenchymal Stromal Cells Can Regulate the Immune Response in the Tumor Microenvironment. Vaccines (Basel). 2016;4(4).
14. Spaeth E, Klopp A, Dembinski J, Andreeff M, Marini F. Inflammation and tumor microenvironments: defining the migratory itinerary of mesenchymal stem cells. Gene Ther. 2008;15(10):730-738.
15. Spaeth EL, Labaff AM, Toole BP, Klopp A, Andreeff M, Marini FC. Mesenchymal CD44 expression contributes to the acquisi- tion of an activated fibroblast phenotype via TWIST activation in the tumor microenvi- ronment. Cancer Res. 2013; 73(17):5347- 5359.
16. Kim JA, Shim JS, Lee GY, et al. Microenvironmental remodeling as a parameter and prognostic factor of heteroge- neous leukemogenesis in acute myeloge- nous leukemia. Cancer Res. 2015; 75(11): 2222-2231.
17. Raaijmakers MH, Mukherjee S, Guo S, et al. Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia. Nature. 2010;464(7290):852-857.
18. Shi C. Recent progress toward understand- ing the physiological function of bone mar- row mesenchymal stem cells. Immunology. 2012;136(2):133-138.
19. Balakrishnan K, Burger JA, Quiroga MP, et al. Influence of bone marrow stromal microenvironment on forodesine-induced responses in CLL primary cells. Blood. 2010;116(7):1083-1091.
20. Kojima K, McQueen T, Chen Y, et al. p53 activation of mesenchymal stromal cells par- tially abrogates microenvironment-mediat- ed resistance to FLT3 inhibition in AML through HIF-1alpha-mediated down-regula- tion of CXCL12. Blood. 2011; 118(16):4431- 4439.
21. Marquez ME, Hernandez-Uzcategui O, Cornejo A, Vargas P, Da Costa O. Bone mar- row stromal mesenchymal cells induce down regulation of CD20 expression on B-
CLL: implications for rituximab resistance in
CLL. Br J Haematol. 2015;169(2):211-218. 22. Xia B, Tian C, Guo S, et al. c-Myc plays part in drug resistance mediated by bone mar- row stromal cells in acute myeloid leukemia.
Leuk Res. 2015;39(1):92-99.
23. Zeng Z, Shi YX, Samudio IJ, et al. Targeting
the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML. Blood. 2009;113(24):6215-6224.
24. Medyouf H, Mossner M, Jann JC, et al. Myelodysplastic cells in patients reprogram mesenchymal stromal cells to establish a transplantable stem cell niche disease unit. Cell Stem Cell. 2014;14(6):824-837.
25. Zhao Y, Wu D, Fei C, et al. Down-regulation of Dicer1 promotes cellular senescence and decreases the differentiation and stem cell- supporting capacities of mesenchymal stro- mal cells in patients with myelodysplastic syndrome. Haematologica. 2015; 100(2):194-204.
26. Oliver L, Hue E, Priault M, Vallette FM. Basal autophagy decreased during the differentia- tion of human adult mesenchymal stem cells. Stem Cells Dev. 2012; 21(15):2779- 2788.
27. Oliver L, Hue E, Rossignol J, et al. Distinct roles of Bcl-2 and Bcl-Xl in the apoptosis of human bone marrow mesenchymal stem cells during differentiation. PLoS One. 2011;6(5):e19820.
Identification of the PKR nuclear interac- tome reveals roles in ribosome biogenesis, mRNA processing and cell division. J Cell Physiol. 2014;229(8):1047-1060.
37. Ali AT, Hochfeld WE, Myburgh R, Pepper MS. Adipocyte and adipogenesis. Eur J Cell Biol. 2013;92(6-7):229-236.
38. Jin W, Takagi T, Kanesashi SN, et al. Schnurri-2 controls BMP-dependent adipo- genesis via interaction with Smad proteins. Dev Cell. 2006;10(4):461-471.
39. Kauppinen A, Suuronen T, Ojala J, Kaarniranta K, Salminen A. Antagonistic crosstalk between NF-kappaB and SIRT1 in the regulation of inflammation and metabol- ic disorders. Cell Signal. 2013;25 (10):1939- 1948.
40. Battula VL, Le PM, Sun JC, et al. AML- induced osteogenic differentiation in mes- enchymal stromal cells supports leukemia growth. JCI Insight. 2017;2(13).
41. Diaz de la Guardia R, Lopez-Millan B, Lavoie JR, et al. Detailed Characterization of Mesenchymal Stem/Stromal Cells from a Large Cohort of AML Patients Demonstrates a Definitive Link to Treatment Outcomes. Stem Cell Reports. 2017;8(6):1573-1586.
42. Tabe Y, Jin L, Tsutsumi-Ishii Y, et al. Activation of integrin-linked kinase is a crit- ical prosurvival pathway induced in leukemic cells by bone marrow-derived stromal cells. Cancer Res. 2007;67(2):684-
28. Kornblau SM, Singh N, Qiu Y, Chen W, 694.
45. Hein AL, Seshacharyulu P, Rachagani S, et al. PR55alpha Subunit of Protein Phosphatase 2A Supports the Tumorigenic and Metastatic Potential of Pancreatic Cancer Cells by Sustaining Hyperactive Oncogenic Signaling. Cancer Res. 2016; 76(8):2243- 2253.
46. Stamos J, Weis W. The β-catenin destruction complex. Cold Spring Harb Perspect Biol 2013:5: a007898.
47. Zhang W, Yang J, Liu Y, et al. PR55 alpha, a regulatory subunit of PP2A, specifically reg- ulates PP2A-mediated beta-catenin dephos- phorylation. J Biol Chem. 2009; 284(34): 22649-22656.
48. Okamura H, Yang D, Yoshida K, Teramachi J, Haneji T. Reduction of PP2A Calpha stim- ulates adipogenesis by regulating the Wnt/GSK-3beta/beta-catenin pathway and PPARgamma expression. Biochim Biophys Acta. 2014;1843(11):2376-2384.
49. Grad JM, Zeng XR, Boise LH. Regulation of Bcl-xL: a little bit of this and a little bit of STAT. Curr Opin Oncol. 2000;12(6):543-549.
50. Desbourdes L, Javary J, Charbonnier T, et al. Alteration Analysis of Bone Marrow Mesenchymal Stromal Cells from De Novo Acute Myeloid Leukemia Patients at Diagnosis. Stem Cells Dev. 2017;26(10): 709-722.
821