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F. Knörr et al.
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haematologica | 2018; 103(3)
Table 1. Cytokine concentrations and clinical characteristics.
Sex Age General condition B symptoms Leukocytosis LDH CRP BM involvement Stage Histology
Male Female ≤9 >9 1 2 3 no yes ≤10/nL>10/nL ≤240 >240 ≤4mg/L >4mg/L Negative Positive I+II III+IV n.commoncommon N=69 N=50 P N=41 N=78 P N=81 N=24 N=14 P N=56 N=63 P N=72 N=47 P N=62 N=57 P N=55 N=64 P N=103 N=16 P N=28 N=88 P N=37 N=50 P
IL-1 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 0.0 0.013 0.0 0.0 n.s. 0.0 0.0 0.043 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s.
IL-2 0.0 0.0 n.s. 0.0 0.0 0.020 0.0 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s.
sIL-2R 94163.8 91444.0 n.s. 82570.5 102780.3 n.s. 63245.2 121650.4 221870.0 <0.001 28242.1 145441.8 <0.001 95534.4 85983.0 n.s. 30878.7 130878.5 <0.001 25329.4 125883.3 <0.001 82290.2 190649.2 0.01 17857.6 118455.5 <0.001 85557.6 89737.8 n.s.
IL-4 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s.
IL-5 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s.
IL-6 0.0 0.0 n.s. 7 0.0 n.s. 0.0 17.1 74.1 <0.001 0.0 14.9 <0.001 0.0 14.9 0.010 0.0 11.0 n.s. 0.0 15.2 <0.001 0.0 30.1 0.011 0.0 13.7 0.002 13.2 0.0 0.047
IL-9 4.5 6.0 n.s. 5.1 2.2 n.s. 0.0 8.0 6.0 n.s. 8.2 4.5 n.s. 2.2 5.1 n.s. 2.2 5.1 n.s. 16.5 2.2 n.s. 4.5 2.6 n.s. 8.2 2.2 n.s. 0.0 32.0 n.s.
IL-10 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 13.2 280.0 <0.001 0.0 37.4 <0.001 0.0 10.3 n.s. 0.0 13.2 n.s. 0.0 6.6 0.044 0.0 236.5 0.003 0.0 6.2 0.020 0.0 0.0 n.s.
IL-12p70 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 0.0 0.024 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s.
IL-13 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 0.013 0.0 0.0 n.s. 0.0 0.0 n.s.
IL-17A 0.0 0.0 n.s. 0.0 0.0 0.018 0.0 0.0 65.9 <0.001 0.0 0.0 n.s. 0.0 69.3 <0.001 0.0 0.0 n.s. 0.0 0.0 0.002 0.0 26.2 0.044 0.0 0.0 n.s. 0.0 0.0 0.018
IL-22 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s.
IL-23 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s.
TNF 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 3.7 0.005 0.0 0.0 n.s. 0.0 0.0 n.s.
IFN 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 0.0 0.040 0.0 0.0 0.04 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 0.0 n.s. 0.0 8.2 0.002 0.0 0.0 0.013 0.0 0.0 n.s.
MIG 286.1 330.6 n.s. 276.4 336.2 n.s. 276.6 338.1 404.5 n.s. 272.3 342.8 0.046 341.1 276.6 n.s. 230.3 377.2 <0.001 278.8 333.5 n.s. 276.4 441.0 0.006 187.7 344.2 <0.001 296.1 339.3 n.s.
IP10 130.3 139.0 n.s. 137.3 138.9 n.s. 118.3 131.9 314.9 0.025 115.5 187.2 0.008 136.9 153.7 n.s. 117.7 251.7 0.003 118.0 183.8 n.s. 118.3 343.9 0.002 102.9 183.8 0.009 130.3 193.2 n.s.
MIP1-α 164.0 121.2 n.s. 214.4 106.5 0.020 134.5 135.8 150.4 n.s. 179.2 116.7 n.s. 126.1 158.3 n.s. 136.9 148.0 n.s. 139.3 134.4 n.s. 148.0 98.9 n.s. 214.2 125.6 n.s. 201.7 132.8 n.s.
MIP1-β 96.3 83.5 n.s. 81.2 96.7 n.s. 86.3 95.1 104.9 n.s. 90.2 89.2 n.s. 94.8 85.7 n.s. 84.2 96.4 n.s. 98.6 85.4 n.s. 90.7 75.7 n.s. 83.5 93.6 n.s. 96.3 94.1 n.s.
MCP1 514.0 501.4 n.s. 450.9 535.5 n.s. 481.7 557.3 744.8 n.s. 450.1 533.5 n.s. 487.5 530.9 n.s. 501.4 511.8 n.s. 460.9 551.9 n.s. 499.6 548.7 n.s. 367.4 535.5 n.s. 583.7 466.4 n.s.
IL-8 40.0 71.1 n.s. 32.1 79.3 0.038 40.0 68.9 100.3 n.s. 50.9 45.0 n.s. 50.9 41.6 n.s. 38.7 64.9 n.s. 64.8 43.6 n.s. 49.5 49.3 n.s. 45.5 43.6 n.s. 40.6 94.8 n.s.
G-CSF 0.0 0.0 n.s. 6.7 0.0 n.s. 0.0 0.0 0.0 n.s. 38.0 0.0 0.035 0.0 0.0 n.s. 0.0 0.0 n.s. 1.1 0.0 n.s. 0.0 0.0 n.s. 48.1 0.0 n.s. 0.0 0.6 n.s.
HGF 2751.1 2488.7 n.s. 2751.1 2488.7 n.s. 2000.9 3146.6 10545.8 <0.001 2013.3 3086.7 0.002 2184.7 3636.6 0.003 2675.9 2811.8 n.s. 2159.4 3111.9 0.006 2678.2 4789.9 n.s. 1677.0 2955.0 0.017 2685.2 3021.0 n.s.
VEGF 1113.5 887.5 n.s. 904.5 1032.5 n.s. 719.2 1254.1 1639.7 0.006 803.9 1213.6 n.s. 873.1 1278.0 n.s. 816.0 1213.6 n.s. 790.2 1239.0 n.s. 1085.4 732.3 n.s. 691.6 1146.1 0.048 933.2 1031.2 n.s.
sCD30 63697.1105707.4 n.s. 79788.9 81300.3 n.s. 63367.9 140824.1 75364.2 n.s. 35553.0 121979.7 0.002 81300.3 79788.9 n.s. 53811.2 125200.9 0.008 46643.1 123590.3 <0.001 84067.9 75992.3 n.s. 11771.9 107003.4 <0.001 125200.9 78485.7 n.s.
Median values of cytokine levels in pg/mL according to clinical parameters of 119 ALCL patients at the time of diagnosis. P values are given when significant differences were found. General condition was grouped as: 1 – no or slight impairment; 2 – moderate or strong impairment; 3 – bedridden and severely ill. Bone marrow (BM) involvement was considered positive if blasts were seen on smears, irrespective of cell numbers. IP-10 could not be measured in one patient. LDH: lactate dehydrogenase, CRP: C-reactive protein.