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Blood cytokine concentrations in ALK-positive ALCL
Correlation of cytokine levels with clinical and laboratory characteristics
Correlations between cytokine concentrations and vari- ous clinical and laboratory characteristics are summarized in Table 1.
Age and sex
There was no significant difference in the median cytokine concentrations between girls and boys. Concentrations of IL- 17a (P=0.018) and MIP-1α (214.4 pg/mL versus 106.5 pg/mL, P=0.02) were higher in patients aged 0 – 9 years (41/119) than in patients over 9 years old. Levels of IL-2 (P=0.02) and IL-8 (32.1 pg/mL versus 79.3 pg/mL, P=0.038) were higher in patients older than 9 years (78/119).
Stage and organ involvement
Patients with Murphy stage III or IV (88/116) had signif- icantly higher concentrations of IL-6 (P=0.002), IL-10 (P=0.02), IFN-γ (P=0.013), IP-10 (P=0.009), MIG (P=0.001), VEGF (P=0.048), HGF (P=0.017), sCD30 (P<0.001), and sIL-2R (P<0.001) compared to patients with a lower stage (Online Supplementary Figure S1).
Bone marrow infiltration, defined as blasts detectable in bone marrow smears, was detected in 16 of the 119 (13.4%) ALCL patients. These patients had significantly higher concentrations of IL-6 (30.1 pg/mL versus 0 pg/mL, P=0.011), IL-10 (281.2 pg/mL versus 0 pg/mL, P=0.003), IL-13 (7/16 versus 18/103 elevated, P=0.013), TNF-α (8/16 versus 20/103 elevated, P=0.005), IFN-γ (8.2 pg/mL versus
Figure 1. Cytokine levels in patients with anaplastic lymphoma kinase-positive anaplastic large cell lymphoma and controls. Logarithmic representation of cytokine levels in pg/mL for 119 ALCL patients at the time of diagnosis, 15 ALCL patients in remission and 11 patients with B-cell non-Hodgkin lymphoma (B-NHL).
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