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Editorials
system to study GGCX and the entire vitamin K cycle. In fact, this group recently used this assay in a high-through- put capacity to screen small molecules that impact the vita- min K cycle, an exercise that would be not possible using prior approaches.16 In summary, this elegant report con- firms the critical role that the propeptide region plays in car- boxylation of VKD proteins and highlights the utility of a novel cell-based assay that enables researchers to study membrane-associated enzymes in their natural, home envi- ronment.
Acknowledgments
FA is supported by Grant T32 H107971 from NHLBI.
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