Page 267 - Haematologica May 2020

Different functions for FXII and PK in sepsis
Table 1. Plasma proteins from infected mice detected by mass spectrometry analysis that were significantly down-regulated, compared to healthy mice.
Accession Protein infected/control
Q00724 Retinol-binding protein 4 0.08
P49182 Heparin cofactor 2 0.19 O70362 Phosphatidylinositol-glycan-specific phospholipase D 0.21 P41317 Mannose-binding protein C 0.32 P01675 Ig kappa chain V-VI region XRPC 44 0.32 P03987 Ig gamma-3 chain C region 0.32 Q61268 Apolipoprotein C-IV 0.33 P26262 Plasma kallikrein 0.37 P42703 Leukemia inhibitory factor receptor 0.38 Q9DBB9 Carboxypeptidase N subunit 2 0.40 P01898 H-2 class I histocompatibility antigen_ Q10 alpha chain 0.42 Q9JJN5 Carboxypeptidase N catalytic chain 0.42 Q07968 Coagulation factor XIII B chain 0.44 Q9Z1R3 Apolipoprotein M 0.44 Q61730 Interleukin-1 receptor accessory protein 0.45 Q8BH61 Coagulation factor XIII A chain 0.45 Q9R098 Hepatocyte growth factor activator 0.46 Q06770 Corticosteroid-binding globulin 0.47 Q8VCS0 N-acetylmuramoyl-L-alanine amidase 0.48 O89020 Afamin 0.49 P33622 Apolipoprotein C-III 0.49 Q60994 Adiponectin 0.50 P01887 Beta-2-microglobulin 0.50 P01642 Ig kappa chain V-V region L7 (Fragment) 0.50 P01863 Ig gamma-2A chain C region_ A allele 0.50 P51885 Lumican 0.51 P07309 Transthyretin 0.51 P03953 Complement factor D 0.53 P13020 Gelsolin 0.53 Q9QWK4 CD5 antigen-like 0.54 Q06890 Clusterin 0.54 P01787 Ig heavy chain V regions TEPC 15/S107/HPCM1/HPCM2/HPCM3 0.55 P29699 Alpha-2-HS-glycoprotein 0.55 P01806 Ig heavy chain V region 441 0.56 Q64726 Zinc-alpha-2-glycoprotein 0.60
P28665 Murinoglobulin-1 0.63
P28666 Murinoglobulin-2 0.64
P14106 Complement C1q subcomponent subunit B 0.64 P01631 Ig kappa chain V-II region 26-10 0.65 Q9ESB3 Histidine-rich glycoprotein 0.65 P01867 Ig gamma-2B chain C region 0.66 P23953 Carboxylesterase 1C 0.66 Q61129 Complement factor I 0.66 P32261 Antithrombin-III 0.66 P01872 Immunoglobulin heavy constant mu 0.66 P01843 Ig lambda-1 chain C region 0.67 P01868 Ig gamma-1 chain C region secreted form 0.67
Anova (P)
2.17E-09
1.50E-05 7.41E-06 2.66E-04 5.87E-04 4.16E-06 5.79E-04 2.42E-04 1.30E-04 8.67E-07 2.00E-04 2.95E-04 3.61E-07 8.43E-04 6.01E-05 1.18E-02 3.31E-04 2.25E-04 1.55E-03 1.28E-06 3.90E-04 1.33E-02 1.98E-03 1.26E-03 2.38E-02 1.81E-03 5.89E-04 2.81E-02 1.87E-04 1.19E-03 6.55E-05 1,75E-02 2.09E-04 2.29E-02 3.34E-05 1.80E-04 2.88E-04 1.23E-02 1.55E-02 1.06E-02 3.93E-02 5.23E-03 3.33E-04 1.07E-03 6.51E-03 2.40E-02 4.62E-03
Fold change
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