Page 263 - Haematologica May 2020

DNM2 is required for GPVI signaling
leukin 5-stimulated signaling pathways by dynamin. J Biol Chem. 2006;281(20):14429- 14439.
11. Sousa LP, Lax I, Shen H, Ferguson SM, De Camilli P, Schlessinger J. Suppression of EGFR endocytosis by dynamin depletion reveals that EGFR signaling occurs primari- ly at the plasma membrane. Proc Natl Acad Sci U S A. 2012;109(12):4419-4424.
12. Tremblay CS, Brown FC, Collett M, et al. Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 sig- nalling. Leukemia. 2016;30(10):1993-2001.
13. Mundell SJ, Barton JF, Mayo-Martin MB, Hardy AR, Poole AW. Rapid resensitization of purinergic receptor function in human platelets. J Thromb Haemost. 2008;6(8): 1393-1404.
14. Rowley JW, Oler AJ, Tolley ND, et al. Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes. Blood. 2011;118(14):e101-111.
15. Burkhart JM, Vaudel M, Gambaryan S, et al. The first comprehensive and quantita- tive analysis of human platelet protein composition allows the comparative analy- sis of structural and functional pathways. Blood. 2012;120(15):e73-82.
16. Nürnberg ST, Rendon A, Smethurst PA, et al. A GWAS sequence variant for platelet volume marks an alternative DNM3 pro- moter in megakaryocytes near a MEIS1 binding site. Blood. 2012;120(24):4859- 4868.
17. Zeiler M, Moser M, Mann M. Copy num- ber analysis of the murine platelet pro- teome spanning the complete abundance range. Mol Cell Proteomics. 2014;13(12): 3435-3445.
18. Lorenz V, Ramsey H, Liu ZJ, et al. Developmental Stage-Specific Manifestations of Absent TPO/c-MPL Signalling in Newborn Mice. Thromb Haemost. 2017;117(12):2322-2333.
19. Falet H, Pollitt AY, Begonja AJ, et al. A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function. J Exp Med. 2010;207(9):1967- 1979.
20. Kanaji T, Kanaji S, Montgomery RR, Patel SB, Newman PJ. Platelet hyperreactivity explains the bleeding abnormality and macrothrombocytopenia in a murine model of Sitosterolemia. Blood. 2013;122(15):2732-2742.
21. Koseoglu S, Dilks JR, Peters CG, et al. Dynamin-related protein-1 controls fusion pore dynamics during platelet granule exo- cytosis. Arterioscler Thromb Vasc Biol. 2013;33(3):481-488.
22. Jones CI, Sage T, Moraes LA, et al. Platelet endothelial cell adhesion molecule-1 inhibits platelet response to thrombin and von Willebrand factor by regulating the internalization of glycoprotein Ib via AKT/glycogen synthase kinase-3/dynamin and integrin alphaIIbbeta3. Arterioscler Thromb Vasc Biol. 2014;34(9):1968-1976.
23. Gao W, Shi P, Chen X, et al. Clathrin-medi- ated integrin alphaIIbbeta3 trafficking con- trols platelet spreading. Platelets. 2018;29(6):617-621.
24. Munday AD, Gaus K, Lopez JA. The platelet
glycoprotein Ib-IX-V complex anchors lipid rafts to the membrane skeleton: implications for activation-dependent cytoskeletal translocation of signaling molecules. J Thromb Haemost. 2010;8(1):163-172.
25. Begonja AJ, Pluthero FG, Suphamungmee W, et al. FlnA binding to PACSIN2 F-BAR domain regulates membrane tubulation in megakaryocytes and platelets. Blood. 2015;126(1):80-88.
26. Nieswandt B, Watson SP. Platelet-collagen interaction: is GPVI the central receptor? Blood. 2003;102(2):449-461.
27. Watson SP, Auger JM, McCarty OJ, Pearce AC. GPVI and integrin alphaIIb beta3 sig- naling in platelets. J Thromb Haemost. 2005;3(8):1752-1762.
28. Ezumi Y, Shindoh K, Tsuji M, Takayama H. Physical and functional association of the Src family kinases Fyn and Lyn with the collagen receptor glycoprotein VI-Fc recep- tor gamma chain complex on human platelets. J Exp Med. 1998;188(2):267-276.
29. Michelson AD, Barnard MR. Thrombin- induced changes in platelet membrane gly- coproteins Ib, IX, and IIb-IIIa complex. Blood. 1987;70(5):1673-1678.
30. Falet H. Anatomy of the Platelet Cytoskeleton. In: Gresele P, Kleiman NS, López JA, Page CP, eds. Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics: an Update: Springer; 2017:139-156.
31. Harrison P, Wilbourn B, Debili N, et al. Uptake of plasma fibrinogen into the alpha granules of human megakaryocytes and platelets. J Clin Invest. 1989;84(4):1320-1324.
32. Handagama P, Scarborough RM, Shuman MA, Bainton DF. Endocytosis of fibrinogen into megakaryocyte and platelet alpha- granules is mediated by alpha IIb beta 3 (glycoprotein IIb-IIIa). Blood. 1993;82(1): 135-138.
33. Lo RW, Li L, Leung R, Pluthero FG, Kahr WHA. NBEAL2 (Neurobeachin-Like 2) Is Required for Retention of Cargo Proteins by alpha-Granules During Their Production by Megakaryocytes. Arterioscler Thromb Vasc Biol. 2018;38(10):2435-2447.
34. Cramer EM, Savidge GF, Vainchenker W, et al. Alpha-granule pool of glycoprotein IIb- IIIa in normal and pathologic platelets and megakaryocytes. Blood. 1990;75(6):1220- 1227.
35. Kaksonen M, Roux A. Mechanisms of clathrin-mediated endocytosis. Nat Rev Mol Cell Biol. 2018;19(5):313-326.
36. Parton RG, del Pozo MA. Caveolae as plas- ma membrane sensors, protectors and organizers. Nat Rev Mol Cell Biol. 2013;14(2):98-112.
37. Guo YH, Hernandez I, Isermann B, et al. Caveolin-1-dependent apoptosis induced by fibrin degradation products. Blood. 2009;113(18):4431-4439.
38. Hansen CG, Bright NA, Howard G, Nichols BJ. SDPR induces membrane curva- ture and functions in the formation of cave- olae. Nat Cell Biol. 2009;11(7):807-814.
39. Banerjee M, Whiteheart SW. The ins and outs of endocytic trafficking in platelet functions. Curr Opin Hematol.
2017;24(5):467-474.
40. Park R, Shen H, Liu L, Liu X, Ferguson SM,
De Camilli P. Dynamin triple knockout cells reveal off target effects of commonly used dynamin inhibitors. J Cell Sci. 2013;126(22):5305-5312.
41. Preta G, Cronin JG, Sheldon IM. Dynasore - not just a dynamin inhibitor. Cell Commun Signal. 2015;13:24.
42. Ezumi Y, Kodama K, Uchiyama T, Takayama H. Constitutive and functional association of the platelet collagen receptor glycoprotein VI-Fc receptor gamma-chain complex with membrane rafts. Blood. 2002;99(9):3250-3255.
43. Quinton TM, Kim S, Jin J, Kunapuli SP. Lipid rafts are required in Galpha(i) signal- ing downstream of the P2Y12 receptor during ADP-mediated platelet activation. J Thromb Haemost. 2005;3(5):1036-1041.
44. Rabie T, Varga-Szabo D, Bender M, et al. Diverging signaling events control the pathway of GPVI down-regulation in vivo. Blood. 2007;110(2):529-535.
45. Gomez TS, Hamann MJ, McCarney S, et al. Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse. Nat Immunol. 2005;6(3):261-270.
46. Pearce AC, Senis YA, Billadeau DD, Turner M, Watson SP, Vigorito E. Vav1 and vav3 have critical but redundant roles in mediat- ing platelet activation by collagen. J Biol Chem. 2004;279(52):53955-53962.
47. Poulter NS, Pollitt AY, Owen DM, et al. Clustering of glycoprotein VI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets. J Thromb Haemost. 2017;15(3): 549-564.
48. Kato K, Kanaji T, Russell S, et al. The con- tribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletion. Blood. 2003;102(5):1701-1707.
49. Morowski M, Vogtle T, Kraft P, Kleinschnitz C, Stoll G, Nieswandt B. Only severe thrombocytopenia results in bleed- ing and defective thrombus formation in mice. Blood. 2013;121(24):4938-4947.
50. Gould WR, Simioni P, Silveira JR, Tormene D, Kalafatis M, Tracy PB. Megakaryocytes endocytose and subsequently modify human factor V in vivo to form the entire pool of a unique platelet-derived cofactor. J Thromb Haemost. 2005;3(3):450-456.
51. Klement GL, Yip TT, Cassiola F, et al. Platelets actively sequester angiogenesis regulators. Blood. 2009;113(12):2835-2842.
52. Burgener R, Wolf M, Ganz T, Baggiolini M. Purification and characterization of a major phosphatidylserine-binding phosphopro- tein from human platelets. Biochem J. 1990;269(3):729-734.
53. Tsai HJ, Huang CL, Chang YW, et al. Disabled-2 is required for efficient hemo- stasis and platelet activation by thrombin in mice. Arterioscler Thromb Vasc Biol. 2014;34(11):2404-2412.
54. Yu CH, Rafiq NB, Cao F, et al. Integrin- beta3 clusters recruit clathrin-mediated endocytic machinery in the absence of trac- tion force. Nat Commun. 2015;6:8672.
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