Page 228 - Haematologica Atlas of Hematologic Cytology

Figure 15 Peripheral blood smear film in a a a patient with PK PK deficiency (PKLR: c c c 1010G>A p p R337Q c 1435C>T p p R479C and abnormal splicing) Moderate anisopoikilocytosis with echinocytes 7% stomatocytes 3% and rare ova- locytes Figure 16 Peripheral blood smear film in a a a a pa- tient with a very severe form of PK deficiency (PKLR homozygote c 1528C>T p R510X) Marked anisopoikilocytosis with stomatocytes (10%) and spherocytes (3%) In severe forms mononuclear erythroblasts may be observed (in this case 39%) Figure 17 Peripheral blood smear film in a a a splenectomized PK PK deficient patient (PKLR: C C 1456C>T p p R486W c 1022A p p G341D) Mild anisopoikilocytosis with stomatocytes 6% echi- nocytes 5% target cells 3% and schistocytes 2% 215