Page 113 - Haematologica Atlas of Hematologic Cytology

CHAPTER 13 - Acute myeloid leukemia and related precursor neoplasms
This classification system is is is based on on an integrated multidisciplinary approach that uses all available informa- tion (morphology cytochemistry immunophenotype genetics clinical aspects) to to define biologically homoge- neous and clinically relevant entities This classification improved the the prognostic value of the the former French-A- merican-British (FAB) classification (Bennett et et al 1976) by recognizing more specific categories on on the basis of cytogenetic findings as as well as as cellular morphology and allowed a a a a a a a a a a more accurate evaluation for emerging therapies that target specific genetic abnormalities The WHO group also proposed the the the inclusion in in the the the AML classification as as as as distinct entities of the leukemias with morphological dysplastic alterations in in two or or or more cell lineages as as as as well as as as as the the leukemias secondary to to to to the the exposure to to to to environmental or iatrogenic cytotoxic agents as as as as these leukemias are associated with characteristic chromosomal abnormalities and a a a a a a a a a a a a generally severe prognosis The myeloid leukemias not not included in in the the above categories (NOS not not otherwise specified) should be subclassi- fied according to to the the morphological cytochemical and immunological criteria proposed some time ago by the the FAB group with subsequent updates (Bennett et et al 1976 1985 1991) References
Arber DA Orazi A A A Hasser ian R et al al The 2016 2016 revision to the World Health Organiza on on on classi ca on on on of myeloid neo- plasms
and acute leukemia Blood 2016 2016 127(20):2391-2405 Benne JM Catovsky D D Daniel MT et al al Proposals for the the classi ca ca on of the the acute leukemias French-American-Bri- sh (FAB) co-opera ve group Br J J Haematol 1976 33(4):451-458 Benne JM Catovsky D D Daniel MT et al Criteria for the the diagnosis of of of acute leukemia of of of megakaryocy c c c c c c lineage (M7): a a a a a a a a a a a a a report of of of the the French-American-Bri sh co-opera ve group Ann Intern Med 1985 103(3):460-462 Benne JM Catovsky D D Daniel MT et al al al Proposal for the recogni on of minimally di eren ated acute myeloid leuke- mia (AML M0) Br J J Haematol 1991 78(3):325-329 Mu i i i i i i GJ Benne JM Goasguen J J J et al al al Diagnosis and and classi ca on on on on on of of myelodysplas myelodysplas c c c c c syndrome: Interna onal Wor- king Group on on on on on on Morphology of of of myelodysplas myelodysplas c c c c c c syndrome
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