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Hydroxyurea in polycythemia vera
Event heterogeneity and timing
No evidence of excess heterogeneity was found in meta-regression for MF (P=0.281) or AML (P=1.000) once adjusted for potential confounders, as opposed to mortal- ity and thrombosis, where a small but non-zero amount of heterogeneity was observed despite adjustment. The
distribution of events during follow up as carried out by meta-regression highlighted a significant effect of age on probability of MF and thrombosis (and obviously on mor- tality), but not of AML (Figure 2 and Online Supplementary Table S1). This effect is particularly strong for thrombosis. Remarkably, history of thrombosis was not a significant
Figure 2. Forest plot of outcomes incidences. The incidence is not graphed for Mesa et al. since its very large Confidence Interval could not fit in the plot, but is accounted for in global estimates. Size of markers annotates study sample size. MF: myelofibrosis; AML: acute myeloid leukemia.
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