Page 57 - 2019_12-Haematologica-web

Disruption of MBD2-NuRD induces high HbF levels
methylated nucleosomes. Genes Dev.
2001;15(7):827-832.
30. Ng HH, Zhang Y, Hendrich B, et al. MBD2
is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. Nat Genet. 1999;23(1):58-61.
31. Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D. Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev. 1999;13(15):1924-1935.
32. Rupon JW, Wang SZ, Gaensler K, Lloyd J, Ginder GD. Methyl binding domain pro- tein 2 mediates gamma-globin gene silenc- ing in adult human betaYAC transgenic mice. Proc Natl Acad Sci U S A. 2006; 103(17):6617-6622.
33. Le Guezennec X, Vermeulen M, Brinkman AB, et al. MBD2/NuRD and MBD3/NuRD, two distinct complexes with different bio- chemical and functional properties. Mol Cell Biol. 2006;26(3):843-851.
34. Harju-Baker S, Costa FC, Fedosyuk H, Neades R, Peterson KR. Silencing of Agamma-globin gene expression during adult definitive erythropoiesis mediated by GATA-1-FOG-1-Mi2 complex binding at the -566 GATA site. Mol Cell Biol. 2008;28(10):3101-3113.
35. Miccio A, Blobel GA. Role of the GATA- 1/FOG-1/NuRD pathway in the expression of human beta-like globin genes. Mol Cell Biol. 2010;30(14):3460-3470.
36. Delaglio F, Grzesiek S, Vuister GW, Zhu G,
Pfeifer J, Bax A. NMRPipe: a multidimen- sional spectral processing system based on UNIX pipes. J Biomol NMR. 1995;6(3):277- 293.
37. Vranken WF, Boucher W, Stevens TJ, et al. The CCPN data model for NMR spec- troscopy: development of a software pipeline. Proteins. 2005;59(4):687-696.
38. Traxler EA, Yao Y, Wang YD, et al. A genome-editing strategy to treat beta- hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition. Nat Med. 2016;22(9):987-990.
39. Cui S, Kolodziej KE, Obara N, et al. Nuclear receptors TR2 and TR4 recruit multiple epi- genetic transcriptional corepressors that associate specifically with the embryonic beta-type globin promoters in differentiat- ed adult erythroid cells. Mol Cell Biol. 2011;31(16):3298-3311.
40. Xu J, Bauer DE, Kerenyi MA, et al. Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A. Proc Natl Acad Sci U S A. 2013;110(16):6518- 6523.
41. Walavalkar NM, Gordon N, Williams DC Jr. Unique features of the anti-parallel, het- erodimeric coiled-coil interaction between methyl-cytosine binding domain 2 (MBD2) homologues and GATA zinc finger domain containing 2A (GATAD2A/p66alpha). J Biol Chem. 2013;288(5):3419-3427.
42. Dever DP, Bak RO, Reinisch A, et al. CRISPR/Cas9 beta-globin gene targeting in human haematopoietic stem cells. Nature.
2016;539(7629):384-389.
43. Dyson HJ, Wright PE. Coupling of folding
and binding for unstructured proteins. Curr
Opin Struct Biol. 2002;12(1):54-60.
44. Fuxreiter M, Simon I, Friedrich P, Tompa P. Preformed structural elements feature in partner recognition by intrinsically unstruc- tured proteins. J Mol Biol. 2004; 338(5):
1015-1026.
45. Shammas SL, Crabtree MD, Dahal L,
Wicky BI, Clarke J. Insights into Coupled Folding and Binding Mechanisms from Kinetic Studies. J Biol Chem. 2016;291(13): 6689-6695.
46. Metallo SJ. Intrinsically disordered proteins are potential drug targets. Curr Opin Chem Biol. 2010;14(4):481-488.
47. Rezaei-Ghaleh N, Blackledge M, Zweckstetter M. Intrinsically disordered proteins: from sequence and conformation- al properties toward drug discovery. Chembiochem. 2012;13(7):930-950.
48. YuC,NiuX,JinF,LiuZ,JinC,LaiL. Structure-based Inhibitor Design for the Intrinsically Disordered Protein c-Myc. Sci Rep. 2016;6:22298.
49. Hendrich B, Guy J, Ramsahoye B, Wilson VA, Bird A. Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development. Genes Dev. 2001;15(6):710-723.
50. Wood KH, Zhou Z. Emerging Molecular and Biological Functions of MBD2, a Reader of DNA Methylation. Front Genet. 2016;7:93.
haematologica | 2019; 104(12)
2371