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Deubiquitylase USP7 and human erythropoiesis
strated in our present study, it will be interesting in future studies to examine whether the altered expression of GATA1 may be associated with changes in USP7 expres- sion in certain blood disorders.
In summary, we have uncovered a previously unrecog- nized role for a deubiquitylase, USP7, in human terminal erythroid differentiation and have identified USP7 as a deubiquitylase of GATA1. Our findings provide new and novel insights into mechanisms of regulating human ery- thropoiesis.
Acknowledgments
This work was supported by the National Key Research and Development Program of China (2018YFA0107800), the Natural Science Foundation of China (81770107,81672760, 81920108004, 81270576, 81800125, 81470362 and 81530005), National Institutes of Health grants (DK100810 and DK32094), the Strategic Priority Research Program of Central South University (zLXD2017004) and the postgraduate innovation project of Central South University (2016zzts165).
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