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Tmem30a in erythropoiesis and EPOR signaling
elucidated a previously, unknown connection among membrane phospholipid partitioning, lipid raft clustering, receptor signal transduction, and erythroid differentiation (Figure 7).
Acknowledgments
The authors would like to thank the National Key Research
and Development Program of China (grants 2016YFA0100602, 2017YFA0103302), National Natural Science Foundation of China (grants 91749203, 81525010, 81420108017 and 81530005), Program for Guangdong Introducing Innovative and Enterpreneurial Teams (2017ZT07S347), and by the Innovative Team Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory (grants 2018GZR110103002).
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Figure 7. Model of Tmem30a function in erythropoiesis. Under normal conditions, upon erythropoietin (EPO) exposure, EPO-receptor (EPOR) localizes to lipid rafts and enhance EPOR-JAK2-STAT5-BCL-XL-Caspase3 signal transduction which is essential for the survival of the embryos during erythropoiesis. In the absence of Tmem30a, lipid raft formation is disturbed, resulting in impaired downstream signal transduction.