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DNMT3A mutation predicts adverse outcome in adult T-ALL
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Figure 3. DNMT3A mutation correlates with poor outcome in T-cell acute lym- phoblastic leukemia. Comparisons of outcomes for patients with (n=18) and without (n=180) DNMT3A mutations are shown for: (A) cumulative incidence of relapse; (B) event-free survival; and (C) overall survival. The 5-year results were as follows: cumulative incidence of relapse 53.9% mutated vs. 28.7% non- mutated; event-free survival 27.8% mutated vs. 61.0% non-mutated; overall sur- vival 38.8% mutated vs. 68.7% non-mutated. P values are indicated.
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Figure 4. DNMT3A genotype predicts outcome in the age group of patients at risk of mutation. Comparisons of outcomes for patients with (n=16) and without (n=34) mutations in patients >40 years are shown for: (A) cumulative incidence of relapse; (B) event-free survival; and (C) overall survival. The 5-year results were as follows: cumulative incidence of relapse 58.3% mutated vs. 21.7% non- mutated; event-free survival, 25.0% mutated vs. 56.7% non-mutated; overall survival 37.5% mutated vs. 62.1% non-mutated. P values are indicated.
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