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Rheb1 regulates HSC proliferation & differentiation
Funding
This work was supported by the funds from the Ministry of Science and Technology of China (2018YFA0107801, 2017YFA0103402, 2017YFA0103302, 2016YFA0100600), National Nature Science Foundation (81870088, 81470280,
81300436, 81770105, 81420108017, 81525010), Chinese Academy of Medical Sciences (CAMS) Initiative for Innovative Medicine CAMS-I2M (2017-I2M-3-015, 2016-I2M-1-017), and PUMC Youth Grant (3332016141, 3332016092, 3332018199).
References
1. Rathinam C, Flavell RA. The hematopoiesis paradigm: clarity or ambigu- ity? Blood. 2008;112(9):3534-3535.
2. Feng CG, Weksberg DC, Taylor GA, Sher A, Goodell MA. The p47 GTPase Lrg-47 (Irgm1) Links Host Defense and Hematopoietic Stem Cell Proliferation. Cell Stem Cell. 2008;2(1):83-89.
3. Hoshii T, Matsuda S, Hirao A. Pleiotropic roles of mTOR complexes in haemato-lym- phopoiesis and leukemogenesis. J Biochem. 2014;156(2):73-83.
4. Guertin DA, Stevens DM, Thoreen CC, et al. Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 is required for sig- naling to Akt-FOXO and PKCĪ±, but not S6K1. Dev Cell. 2006;11(6):859-871.
5. Patel PH, Thapar N, Guo L, et al. Drosophila Rheb GTPase is required for cell cycle progression and cell growth. J Cell Sci. 2003;116(17):3601-3610.
6. Saucedo LJ, Gao X, Chiarelli DA, Li L, Pan D, Edgar BA. Rheb promotes cell growth as a component of the insulin/TOR signalling network. Nat Cell Biol. 2003;5(6):566-571.
7. Neuman NA, Henske EP. Non-canonical functions of the tuberous sclerosis com- plex-Rheb signalling axis. EMBO Mol Med. 2011;3(4):189-200.
8. InokiK,LiY,XuT,GuanKL.RhebGTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev. 2003;17(15):1829-1834.
9. Zhang Y, Gao X, Saucedo LJ, et al. Rheb is
a direct target of the tuberous sclerosis tumour suppressor proteins. Nat Cell Biol. 2003;5(6):578-581.
10. Ma XM, Blenis J. Molecular mechanisms of mTOR-mediated translational control. Nat Rev Mol Cell Biol. 2009;10(5):307-318.
11. Kalaitzidis D, Sykes SM, Wang Z, et al. mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leuke- mogenesis. Cell Stem Cell. 2012;11(3):429- 439.
12. Gan B, Sahin E, Jiang S, et al. mTORC1- dependent and -independent regulation of stem cell renewal, differentiation, and mobilization. Proc Natl Acad Sci USA. 2008;105(49):19384-19389.
13. Karbowniczek M, Zitserman D, Khabibullin D, et al. The evolutionarily conserved TSC/Rheb pathway activates Notch in tuberous sclerosis complex and Drosophila external sensory organ develop- ment. J Clin Invest. 2010;120(1):93-102.
14. Karbowniczek M, Robertson GP, Henske EP. Rheb inhibits C-raf activity and B-raf/C- raf heterodimerization. J Biol Chem. 2006; 281(35):25447-25456.
15. MaD,BaiX,ZouH,LaiY,JiangY.Rheb GTPase controls apoptosis by regulating interaction of FKBP38 with Bcl-2 and Bcl- XL. J Biol Chem. 2010;285(12):8621-8627.
16. Wang X, Li M, Gao Y, et al. Rheb1- mTORC1 maintains macrophage differen- tiation and phagocytosis in mice. Exp Cell Res. 2016;344(2):219-228.
17. Zou J, Zhou L, Du XX, et al. Rheb1 is required for mTORC1 and myelination in postnatal brain development. Dev Cell. 2011;20(1):97-108.
18. Lu W, Han L, Su L, et al. A 3'UTR-associat- ed RNA, FLJ11812 maintains stemness of human embryonic stem cells by targeting miR-4459. Stem Cells Dev. 2015; 24(9):1133-1140.
19. Zhu H, Guo ZK, Jiang XX, et al. A protocol for isolation and culture of mesenchymal stem cells from mouse compact bone. Nat Protoc. 2010;5(3):550-560.
20. Challen GA, Sun D, Mayle A, et al. Dnmt3a and Dnmt3b Have Overlapping and Distinct Functions in Hematopoietic Stem Cells. Cell Stem Cell. 2014;15(3):350-364.
21. Orazi A, Germing U. The myelodysplas- tic/myeloproliferative neoplasms: myelo- proliferative diseases with dysplastic fea- tures. Leukemia. 2008;22(7):1308-1319.
22. Rumman M, Dhawan J, Kassem M. Concise Review: Quiescence in Adult Stem Cells: Biological Significance and Relevance to Tissue Regeneration. Stem Cells. 2015; 33(10):2903-2912.
23. Wilson A, Laurenti E, Oser G, et al. Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell. 2008;135(6): 1118-1129.
24. Peng H, Kasada A, Ueno M, et al. Distinct roles of Rheb and Raptor in activating mTOR complex 1 for the self-renewal of hematopoietic stem cells. Biochem Biophys Res Commun. 2018;495(1):1129-1135.
25. Fiedler K, Sindrilaru A, Terszowski G, et al. Neutrophil development and function critically depend on Bruton tyrosine kinase in a mouse model of X-linked agammaglobulinemia. Blood. 2011;117(4): 1329-1339.
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