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Fusion genes involving MEF2D in B-ALL
Results
Detection of MEF2D fusions in pediatric B-ALL patients
tified 9 and 6 patients with MEF2D-BCL9 and MEF2D- HNRNPUL1, respectively (Table 1, Online Supplementary Table S1 and S3, Figure 1 and Online Supplementary Figure S1). Of note, one case of each abnormality was identified
Among the 328 selected RNA samples from B-ALL by gene expression profiling (details in Online patients (Online Supplementary Figure S1) analyzed by WTS Supplementary Information). We also identified an additional and/or RT-PCR followed by Sanger sequencing, we iden- case with MEF2D-BCL9 (Table 1, Case 10) in B-LBL. As
Figure 1. Structures of the MEF2D fusions. Structures of fusion proteins and nucleotide sequences of (a) - (e) MEF2D-BCL9, (f) MEF2D-HNRNPUL1, (g) and (h) MEF2D-HNRNPH1. The red arrowhead shows the donor and acceptor site breakpoint. The number of patients in whom a particular fusion isoform was found is indi- cated on the right.
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