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T. Toya et al.
the prognostic factors for this disease were age >60 years old at the onset (P<0.0001), lack of bone lesions (P<0.0001), and the involvement of the CNS (P=0.0010) and digestive organs (P=0.017) (Figure 1B-E). In contrast, the presence of cardiovascular disease, endocrinosis, and pulmonary, kidney/retroperitoneal and cutaneous lesions was not considered as a prognostic factor (Online
Supplementary Figure S2). Patients with only one ECD lesion, all of whom had a bone lesion, tended to have bet- ter survival after the onset of the disease than those with multiple lesions, although this difference was not statisti- cally significant, perhaps because the number of patients who had a single lesion was only five (P=0.064).
The univariate analyses, which were conducted using
AB
C
D
E
Figure 1. Survival curves of patients with Erdheim–Chester disease. Kaplan– Meier estimation for survival from onset of (A) all 44 patients based on (B) age and presence of (C) bone lesions, (D) central nervous system involvement, and (E) digestive involvement. CNS: central nervous system; DO: digestive organ.
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haematologica | 2018; 103(11)