Page 144 - 2018_10-Haematologica-web

S. Nikiforow et al.
Table 2. Demographics of subgroups with isolated UGI aGvHD or other stages without GI symptoms.
Characteristics of patients
Number of patients Number of centers
Patient-related
Age at transplant, years, median (range) Sex
Male
Female Race
No aGVHD
3428 221
42 (18 - 72)
1805 (53) 1623 (47)
2814 (82)
2296 (67)
1749 (51) 736 (21) 600 (18) 343 (10)
1836 (54) 772 (23) 806 (24)
2038 (59) 1048 (31) 342 (10) 40 (<1 - 85)
1150 (34) 909 (27) 655 (19) 712 (21)
1311 (38) 320 (9) 794 (23) 808 (24)
1936 (56)
Grade I (Skin 1/2)
1344 165
43 (18 - 70)
745 (55) 599 (45)
1179 (88) 961 (72)
694 (52) 282 (21) 242 (18) 126 (9)
750 (56) 288 (21) 303 (23)
654 (49) 542 (40) 148 (11) 43 (<1 - 68)
494 (37) 361 (27) 250 (19) 238 (18)
411 (31) 146 (11) 363 (27) 368 (27)
719 (53)
7 (<1 - 177)
413 (31) 931 (69) 708 (53) 183 (14) 109 (8)
Grade II No UGI
1211 165
41 (18 - 71)
712 (59) 499 (41)
1068 (88) 830 (69)
554 (46) 276 (23) 220 (18) 161 (13)
699 (58) 248 (20) 258 (21)
477 (39) 541 (45) 193 (16) 41 (<1 - 70)
456 (38) 291 (24) 255 (21) 208 (17)
367 (30) 125 (10) 306 (25) 342 (28)
636 (53)
7 (1 - 279)
331 (27) 880 (73) 648 (54) 115 (9) 136 (11)
iUGI
229 61
43 (18 - 68)
127 (55) 102 (45)
201 (88)
142 (62)
118 (52) 49 (21) 35 (15) 27 (12)
115 (50) 66 (29) 48 (21)
81 (35) 119 (52) 29 (13) 43 (14 - 70)
75 (33) 55 (24) 52 (23) 47 (21)
62 (27) 20 (9) 84 (37) 50 (22)
120 (52)
6 (1 - 213)
56 (24) 173 (76) 113 (49) 11 (5) 19 (8)
Grade III-IV No UGI
1545 192
42 (18 - 72)
933 (60) 612 (40)
1304 (84) 991 (64)
675 (44) 338 (22) 343 (22) 189 (12)
777 (50) 331 (21) 426 (28)
584 (38) 638 (41) 323 (21) 42 (3 - 74)
589 (38) 346 (22) 344 (22) 266 (17)
476 (31) 160 (10) 390 (25) 429 (28)
777 (50)
7 (<1 - 309)
439 (28) 1106 (72) 800 (52) 221 (14) 223 (14)
749 (48)
Caucasian
Karnofsky performance score at HSCT
≥ 90% Disease AML
ALL CML MDS
Disease status at transplant Early
Intermediate
Advanced
Donor-related Donor type
HLA-identical sibling URD well-matched URD partially-matched
HLA-identical sibling donor age,
years, median (range)
Unrelateddonorage,years, 32(19-61) 33(19-60) 34(18-60) 32(19-59) 35(19-61) median (range)
D/R sex match
M/M M/F F/M F/F
D/R CMV status +/+
+/- -/+ -/-
D/R ABO match Matched
Transplant-related
Time from diagnosis to transplant, months, 7 (<1 - 310) median (range)
Graft type
Bone marrow
Peripheral blood
TBI used in conditioning regimen Steroid-containing GvHD prophylaxis MMF-containing GvHD prophylaxis Year of transplant
1057 (31) 2371 (69) 1672 (49) 392 (11) 304 (9)
2000-2004
1549 (45)
582 (43)
518 (43)
65 (28)
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haematologica | 2018; 103(10)