Page 311 - Haematologica Vol. 109 - July 2024

LETTER TO THE EDITOR
©2024 Ferrata Storti Foundation Published under a CC BY-NC license
Disclosures
No conflicts of interest to disclose.
Contributions
RMS performed the statistical analysis, interpreted data, and wrote the statistical section of the manuscript. SJL, PAC, JRH, CJL, AA, GC, MD, REC, KR, and EJS reviewed and interpreted the data, reviewed the manuscript, and provided critical feedback. RSM and RMS conceptualized the study design and interpreted data. RSM wrote the manuscript with the help of RMS. RMS and RSM had full access to the raw data which is publicly available. All authors approved the manuscript. The corresponding author had the final responsibility for submitting the manuscript for publication.
References
1. Ueda Oshima M, Xie H, Zamora D, et al. Impact of GVHD prophylaxis on CMV reactivation and disease after HLA- matched peripheral blood stem cell transplantation. Blood Adv. 2023;7(8):1394-1403.
2. Teira P, Battiwalla M, Ramanathan M, et al. Early cytomegalovirus reactivation remains associated with increased transplant-related mortality in the current era: a CIBMTR analysis. Blood. 2016;127(20):2427-2438.
3. CIBMTR. https://cibmtr.org/CIBMTR/Resources/Publicly- Available-Datasets#. Accessed 9/6/2023.
4. Arrieta-Bolanos E, Crivello P, He M, et al. A core group of structurally similar HLA-DPB1 alleles drives permissiveness after hematopoietic cell transplantation. Blood. 2022;140(6):659-663.
5. Gooptu M, Romee R, St Martin A, et al. HLA-haploidentical vs matched unrelated donor transplants with posttransplant cyclophosphamide-based prophylaxis. Blood. 2021;138(3):273-282.
6. Nachbaur D, Bonatti H, Oberaigner W, et al. Survival after bone marrow transplantation from cytomegalovirus seropositive sibling donors. Lancet. 2001;358(9288):1157-1159.
7. Elmaagacli AH, Koldehoff M. Cytomegalovirus replication reduces the relapse incidence in patients with acute myeloid leukemia. Blood. 2016;128(3):456-459.
8. Beziat V, Liu LL, Malmberg JA, et al. NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs. Blood. 2013;121(14):2678-2688.
Acknowledgments
We thank the Center for International Blood and Marrow Transplant Research (CIBMTR) staff for providing the dataset used in this study.
Funding
This dataset was collected by the CIBMTR which is supported primarily by the Public Health Service U24CA076518 from the National Cancer Institute; the National Heart, Lung, and Blood Institute; the National Institute of Allergy and Infectious Diseases; 75R60222C00011 from the Health Resources and Services Administration; N00014-21-1-2954 and N00014-23-1-2057 from the Office of Naval Research; the National Marrow Donor Program/Be The Match; and the Medical College of Wisconsin.
Data-sharing statement
The data are publicly available and accessible at https://cibmtr.org/ CIBMTR/Resources/Publicly-Available-Datasets.
9. Foley B, Cooley S, Verneris MR, et al. Cytomegalovirus reactivation after allogeneic transplantation promotes a lasting increase in educated NKG2C+ natural killer cells with potent function. Blood. 2012;119(11):2665-2674.
10. Ohata K, Espinoza JL, Lu X, Kondo Y, Nakao S. Mycophenolic acid inhibits natural killer cell proliferation and cytotoxic function: a possible disadvantage of including mycophenolate mofetil in the graft-versus-host disease prophylaxis regimen. Biol Blood Marrow Transplant. 2011;17(2):205-213.
11. Ruggeri L, Capanni M, Casucci M, et al. Role of natural killer cell alloreactivity in HLA-mismatched hematopoietic stem cell transplantation. Blood. 1999;94(1):333-339.
12. Green ML, Leisenring WM, Xie H, et al. CMV reactivation after allogeneic HCT and relapse risk: evidence for early protection in acute myeloid leukemia. Blood. 2013;122(7):1316-1324.
13. Manjappa S, Bhamidipati PK, Stokerl-Goldstein KE, et al. Protective effect of cytomegalovirus reactivation on relapse after allogeneic hematopoietic cell transplantation in acute myeloid leukemia patients is influenced by conditioning regimen. Biol Blood Marrow Transplant. 2014;20(1):46-52.
14. Mariotti J, Maura F, Spina F, et al. Impact of cytomegalovirus replication and cytomegalovirus serostatus on the outcome of patients with B cell lymphoma after allogeneic stem cell transplantation. Biol Blood Marrow Transplant. 2014;20(6):885-890.
15. Degli-Esposti MA, Hill GR. Immune control of cytomegalovirus reactivation in stem cell transplantation. Blood. 2022;139(9):1277-1288.
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