Page 127 - Haematologica July

4/5 (44%/56%) 78 (55-84) 5/9 (56%)
0 (0%)
0 (0%)
1471 (1105-2035) 1406 (711-2313) NS
821 (461-1186) 792 (295-1327) NS
452 (374-900) 491 (245-1469) NS
4.3 (0.97-17) 4.7 (2.3-13)
7y follow-up of monoclonal B-cell lymphocytosis
Table 4. Clinical and biological characteristics of CLL-like MBLlo subjects at baseline and at follow-up (+7 years) according to the kinetics of the MBL clone in PB (decreased/stable vs. increased size).
CLL-like MBLlo subjects (n=56) P
Decrease/stable B-cell clones (n=9)
Male/Female*
Age at baseline, years
Monoclonal at follow-up*
Leukocytosis (>10x109/L) at follow-up *
Lymphocytosis (>4x109/L) at follow-up *
N. total T cells/μL
Baseline
follow-up
P
N. CD4+ T cells/mL
Baseline
follow-up
P
N. CD8+ T cells/mL
Baseline
follow-up
P
N. CD4+/CD8+ T cells/mL
Baseline
follow-up
P NS
N. CD4–/CD8– T cells/mL
Baseline 70 (8.2-214) follow-up 60 (7.2-272) P NS
N. total B cells/mL
Baseline 110 (41-263) follow-up 80 (29-390) P NS
N. normal B cells/mL
Baseline
follow-up
P
N. clonal B cells/mL
Baseline
follow-up
P
% clonal B cells
Baseline
follow-up
P
N. NK cells/mL
Baseline
follow-up
P
Cytogenetic alterations
Baseline
follow-up
P
del(13q14)(D13S25)
Baseline
follow-up
Increased B-cell clones (n=47)#
18/29 (38%/62%) NS 68 (43-81) 0.03 30/47 (64%) NS
2 (4%) NS 2 (4%) NS
1285 (341-2428) NS 1520 (460-3753) NS
<0.01
448 (253-1572) NS 908 (227-2045) NS
<0.01
448 (72-1154) NS 467 (96-1742) NS
0.02
4.6 (0.55-37) NS 8.6 (1.3-147) 0.03
<0.001
58 (8.0-190) NS 65 (1.9-338) NS
0.02
139 (50-1066) NS 175 (28-1218) 0.02
<0.01
122 (50-478) NS 140 (27-536) NS
0.03
0.71 (0.03-66) NS 2.0 (0.10-808) 0.03
<0.001
0.53 (0.02-21) NS 1.0 (0.06-66) NS
<0.001
292 (76-1138) NS 361 (87-3415) NS
<0.01
6/15 (38%) NS 26/41 (63%) NS
0.14
5/13 (39%); 57±38% NS 21/39 (54%); 37±29% NS
94 (37-256) 79 (26-389) NS
0.80 (0.13-23) 0.60 (0.05-3.2) 0.02
0.92 (0.10-20) 0.44 (0.04-10) 0.05
304 (167-874) 492 (310-1066) NS
0/4 (0%) 6/9 (67%) 0.03
0/2 (0%)
6/9 (67%); 17±9%
haematologica | 2018; 103(7)
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