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Effects of HC and IFN-α on PV RBC adhesion
Table 2. ITRAQ ratios of 53 proteins modulated by hydroxycarbamide (HC) in polycythemia vera (PV) red blood cell ghosts.
Protein
Hemoglobin subunit gamma-1
Lu/BCAM
Gene
HBG1
BCAM
HSD17B11 VPS4A DKFZp779L0468
PVHC PV
PV1HC PV2HC
PV1 PV2 PV3
15.0 6.9 1.7
11.8 6.6 9.5
9.0 2.4 8.9 8.7 2.1 4.4 8.6 1.3 8.7
Estradiol 17-β-dehydrogenase 11
Vacuolar protein sorting-associated protein 4A cAMP-dependent protein kinase type I-α regulatory subunit Atlastin-3
ATL3 5.6 1.2 2.2
PV3HC
ATP-binding cassette sub-family G member 2 ABCG2 4.7 2.5 99.1 Kell blood group. Metallo-endopeptidase KEL 4.4 1.5 6.5
Monocarboxylate transporter 1 SLC16A1 3.6 2.8 12.9 Membrane-associated progesterone receptor component 2 PGRC2 3.0 2.6 4.4
RAB1B protein RAB1B 2.8 1.2 2.2 Gamma-adducin ADD3 2.6 1.2 1.5
Membrane transport protein XK XK 2.6 1.5 4.4 Phosphatidylinositide phosphatase SAC1 SACM1L 2.3 2.4 4.4
Rh-associated glycoprotein RHAG 2.2 1.2 5.5 Extended synaptotagmin-2 ESYT2 2.2 6.2 6.2
Solute carrier family 2. Facilitated glucose transporter member 1 SLC2A1 2.1 1.3 3.9 Vesicle-trafficking protein SEC22b SEC22B 2.1 1.4 6.8
Heat shock cognate 71 kDa protein HSPA8 2.1 3.2 10.4
Basigin (CD147) hEMMPRIN 1.9 2.0 4.8
Plasma membrane calcium-transporting ATPase 4 ATP2B4 1.9 1.3 2.8 Heat shock 70 kDa protein 1A/1B HEL-S-103 1.9 4.4 4.4
Lysophospholipid acyltransferase 2 MBOAT2 1.8 1.2 1.3 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 RPN1 1.8 5.1 2.1
Vacuolar protein sorting-associated protein 13A VPS13A 1.7 6.9 2.9 Multidrug resistance-associated protein 5 ABCC5 1.5 1.2 2.2
Ras-related protein Rab-8A RAB8A 1.5 2.5 1.8 Putative uncharacterized protein DKFZp686H20196 DKFZp686H20196 1.5 15.7 2.0
ADP-ribosylation factor-like protein 6-interacting protein 1 ARL6IP1 1.4 1.4 1.3 Neutral cholesterol ester hydrolase 1 NCEH1 1.4 1.4 1.4
Calcium and integrin-binding protein 1 CIB1 1.4 1.3 1.3 Abhydrolase domain-containing protein 16A ABHD16A 1.3 2.3 4.5
Mannose-P-dolichol utilization defect 1 protein MPDU1 1.3 2.4 14.7 Dolichyl-phosphate β-glucosyltransferase ALG5 1.3 1.2 2.9
LEM domain-containing protein 2 LEMD2 1.3 1.6 1.3 F-actin-capping protein subunit α-1 CAPZA1 1.2 1.7 1.4
Large neutral amino acids transporter small subunit 3 SLC43A1 1.2 1.7 1.5 ATP-citrate synthase ACLY 0.7 0.7 0.3
TXNDC5 protein
Phosphatidylinositol 5-phosphate 4-kinase type-2 α AP complex subunit β
Raichu404X
Tropomyosin α-3 chain
Galectin-3
TXNDC5 0.7 0.7 0.4 PIP4K2A 0.6 0.6 0.5 AP2B1 0.4 0.6 0.6 Raichu404X 0.4 0.7 0.6 TPM3 0.4 0.1 0.1 LGALS3 0.4 0.7 0.0
Small conductance potassium channel type 4 transcript variant 4 KCNN4 0.3 0.3 0.5 ATP-dependent 6-phosphofructokinase PFKM 0.3 0.2 0.2
Ras-related C3 botulinum toxin substrate 1 RAC1 0.2 0.4 0.8 AP-2 complex subunit α-1 AP2A1 0.2 0.4 0.5
Cell division control protein 42 homolog CDC42 0.1 0.6 0.7 AP-2 complex subunit mu AP2M1 0.1 0.4 0.7
Epididymis secretory protein Li 109 HEL-S-109 0.1 0.1 0.1 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0 0.0 0.0
Apolipoprotein A-I APOA1 0.0 0.2 0.1
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