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Figure 4. Assessment of genes showing concor- dant or discordant expression with RGS1, LDOC1 and L3MBTL4. (A) Venn diagram illustrat- ing overlaps for differentially expressed genes (fold-change [FC] >1.5; false discovery rate [FDR] <0.01) between patient samples with either high or low expression (upper vs. lower quartile) for RGS1, LDOC1 and L3MBTL4. (B) Heatmap showing clustered expression pattern (Pearson correlation and average linkage) of 12 genes found in all three gene specific signatures and heatmap showing expression pattern of 51 genes found in gene specific signatures of LDOC1 and L3MBTL4. (C) Scatter plots for ZAP70 expression with regard to groups showing high and low LDOC1 and L3MBTL4 expression (upper vs. lower quartile).
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