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M.J. Stubbs et al.
Contributions
MJS designed research, recruited patients, performed research, collected data, analyzed and interpreted data, wrote the manuscript; PC designed research, recruited patients, ana- lyzed and interpreted data, wrote the manuscript; CC, SD, VP and APL performed research, collected data, analyzed and inter- preted data, wrote the manuscript; AV designed research, recruited patients, analyzed and interpreted data, wrote the manuscript; MT designed research, recruited patients, analysed and interpreted data, wrote the manuscript; JOC designed research, wrote the manuscript; MH designed research, wrote the manuscript; YB, LG and PP designed research, recruited patients, wrote the manuscript; RK, DPG, HS and MAS designed research, performed research, analyzed and interpreted data, wrote the manuscript.
Acknowledgments
We would like to thank Drs Fairfax, Makino, and Knight from the University of Oxford for sharing ethnically matched control data. We would also like to acknowledge the significant contribution of our collaborators within in UK TTP Registry and the French Reference Center for Thrombotic Microangiopathies, who are listed below:
The members of the UK TTP Registry are:
Aberdeen Royal Infirmary (H. Watson, M. Greiss, J. Dixon, S. Rodwell, M. Fletcher), Addenbrookes Hospital (W. Thomas, S. MacDonald), Bath Royal United Hospitals (S. Moore, C. Cox), Birmingham University Hospitals (W. Lester, G. Lowe, C. Percy, E. Dwenger, M. Pope), Birmingham Children’s Hospital (J. Motwani), Bournemouth and Christchurch Hospitals, (S. Killick, M. Serrano), Bristol University Hospitals (A. Clark, A. Mumford, L. Humphrey, S. Mulligan), Cardiff & Vale University Hospitals (R. Rayment, P. Collins, M. Norton, A. Guerrero, S. Cunningham), Cornwall Hospitals NHS Trust (D. Beech, S. Hunter, B. Mills), Coventry & Warwickshire University Hospitals (O. Chapman, B. Bailiff, A. Pearson, D. Morris), Edinburgh Royal Infirmary (L. Manson, N. Priddee), Glasgow Royal Infirmary (K. Douglas, C. Tait, C. Bagot), Glasgow Royal Hospital for Children (E. Chalmers), Great Ormand Street Hospital (R. Liesner, K. Sibson, A. Taylor, A. Griffien), Guy's & St Thomas' NHS Trust (B. Hunt, J. Young), Imperial College NHS Trust (N. Cooper, A. Luqmani, C. Vladescu, D. Paul), Leeds Teaching Hospital NHS Trust (Q. Hill), Leicester Hospitals (R. Gooding, K. Siguake), Royal Liverpool Hospital (T. Dutt, C. Powell), Manchester Children’s Hospital (J. Thachil, J. Granger, S. Boydell), Newcastle Hospitals (T. Biss, J. Wallis, J. Hanley, K. Talks, A. Charlton), Norfolk and Norwich University Hospitals NHS Foundation Trust (H. Lyall, E. Malone, M. Sheridan), Nottingham University Hospitals NHS Trust (G. Swallow, J. Hermans), Oxford University Hospital NHS Trust (S. Benjamin, C. Deane, A. Eordogh, K. Santos), Oxford Children’s Hospital (N. Bhatnager, S. Pavord, G. Hall, P. Baker), Plymouth University Hospitals NHS Trust (T. Nokes), Poole Hospital NHS Foundation Trust (F. Jack, N. Beamish, A. Wandowski), Portsmouth Hospitals NHS Trust (T. Cranfield, C. James, S. Liu), Royal Devon & Exeter NHS Foundation Trust (J. Coppell, L. Ngu), Sheffield Teaching Hospital NHS Foundation Trust (J. Vanveen, M. Makris, R. MacLean, K. Harrington, S. Megson, R. Fretwell), South Tees Hospitals NHS Foundation Trust (R. Dang, M. David, J. Maddox, D. Winterburn), South Warwickshire NHS Foundation Trust (P. Rose), St George’s University Hosptials NHS Foundation Trust (S. Austin, J. Uprichard, J. Chackathayil, A. Lee), University College London Hospitals (M. Scully, J.P. Westwood, M. Thomas, R. Newton,
S. McGuckin, I. Obu, C. Vendramin, L. Keogh, J. Shin, M. Stubbs), NHSBT (K. Pendry, K. Slevin) and Southampton University Hospital NHS Foundation Trust (S. Boyce).
The members of the French Reference Center for Thrombotic Microangiopathies (CNR-MAT) are: Augusto Jean-François (Service de Néphrologie, Dialyse et Transplantation; CHU Larrey, Angers); Azoulay Elie (Service de Réanimation Médicale, Hôpital Saint-Louis, Paris); Barbay Virginie (Laboratoire d’Hématologie, CHU Charles Nicolle, Rouen); Benhamou Ygal (Service de Médecine Interne, CHU Charles Nicolle, Rouen); Bordessoule Dominique (Service d’Hématologie, Hôpital Dupuytren, Limoges); Charasse Christophe (Service de Néphrologie, Centre Hospitalier de Saint-Brieuc); Charvet-Rumpler Anne (Service d’Hématologie, CHU de Dijon); Chauveau Dominique (Service de Néphrologie et Immunologie Clinique, CHU Rangueil, Toulouse); Choukroun Gabriel (Service de Néphrologie, Hôpital Sud, Amiens); Coindre Jean-Philippe (Service de Néphrologie, CH Le Mans); Coppo Paul (Service d’Hématologie, Hôpital Saint- Antoine, Paris); Corre Elise (Service d’Hématologie, Hôpital Saint-Antoine, Paris); Delmas Yahsou (Service de Néphrologie, CHU de Bordeaux, Bordeaux); Deschenes Georges (Service de Néphrologie Pédiatrique, Hôpital Robert Debré, Paris); Devidas Alain (Service d’Hématologie, Hôpital Sud-Francilien, Corbeil- Essonnes); Dossier Antoine (Service de Néphrologie, Hôpital Bichat, Paris); Fain Olivier (Service de Médecine Interne, Hôpital Saint-Antoine, Paris); Fakhouri Fadi (Service de Néphrologie, CHU Hôtel-Dieu, Nantes); Frémeaux-Bacchi Véronique (Laboratoire d’Immunologie, Hôpital Européen Georges Pompidou, Paris); Galicier Lionel (Service d’Immunopathologie, Hôpital Saint-Louis, Paris); Grangé Steven (Service de Réanimation Médicale, CHU Charles Nicolle, Rouen); Guidet Bertrand (Service de Réanimation Médicale, Hôpital Saint-Antoine, Paris); Halimi Jean-Michel (Service de Néphrologie Pédiatrique, Hôpital Bretonneau, Tours); Hamidou Mohamed (Service de Médecine Interne, Hôtel-Dieu, Nantes); Hié Miguel (Service de Médecine Interne, Groupe Hospitalier Pitié-Salpétrière, Paris); Jacobs Frédéric (Service de Réanimation Médicale, Hôpital Antoine Béclère, Clamart); Joly Bérangère (Service d’Hématologie Biologique, Hôpital Lariboisière, Paris); Kanouni Tarik (Unité d’Hémaphrèse, Service d’Hématologie, CHU de Montpellier); Kaplanski Gilles (Service de Médecine Interne, Hôpital la Conception, Marseille); Lautrette Alexandre (Hôpital Gabriel Montpied, Service de Réanimation Médicale, Clermont- Ferrand); Le Guern Véronique (Unité d’Hémaphérèse, Service de Médecine Interne, Hôpital Cochin, Paris); Mariotte Eric (Service de Réanimation, Hôpital Saint-Louis, Paris); Moulin Bruno (Service de Néphrologie, Hôpital Civil, Strasbourg); Mousson Christiane (Service de Néphrologie, CHU de Dijon); Ojeda Uribe Mario (Service d’Hématologie, Hôpital Emile Muller, Mulhouse); Ouchenir Abdelkader (Service de Réanimation, Hôpital Louis Pasteur, Le Coudray); Parquet Nathalie (Unité de Clinique Transfusionnelle, Hôpital Cochin, Paris); Peltier Julie (Urgences Néphrologiques et Transplantation Rénale, Hôpital Tenon, Paris); Pène Frédéric (Service de Réanimation Médicale, Hôpital Cochin, Paris); Perez Pierre (Service de Réanimation Polyvalente, CHU de Nancy); Poullin Pascale (Service d’Hémaphérèse et d’Autotransfusion, Hôpital la Conception, Marseille); Pouteil- Noble Claire (Service de Néphrologie, CHU Lyon-Sud, Lyon); Presne Claire (Service de Néphrologie, Hôpital Nord, Amiens); Provôt François (Service de Néphrologie, Hôpital Albert Calmette, Lille); Rondeau Eric (Urgences Néphrologiques et Transplantation Rénale, Hôpital Tenon, Paris); Saheb Samir
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