Page 15 - 2022_03-Haematologica-web
P. 15

Editorials
also known as ‘Obamacare’), which expanded Medicaid eligibility. The authors report reduced early mortality in post-ACA versus pre-ACA patients, and also that location of care played a key role: Patients diagnosed/treated at National Cancer Institute-Designated Cancer Centers had lower mortality rates and better overall survival than did patients treated elsewhere.
This report is important in several areas that help to clarify previous observations (and the discordance among observations). First, it underscores that in APL, healthcare access is at least as important as are other factors influ- encing early deaths. Indeed, in the absence of timely access, none of the other factors - early diagnosis, imme- diate ATRA availability, vigorous correction of coagu- lopathy, etc. - really matters. As a Canadian enjoying uni- versal healthcare access, I am moved by this realization. Second, treaters’ experience and expertise with APL are important. This study confirms previous suggestions regarding better APL outcomes at ‘teaching’ or ‘universi- ty’ hospitals. And third, the improved outcomes over time in this report suggest that efforts to eradicate early deaths have been effective, at least in part, and provide hope that with further efforts, we can solve the problem of early deaths in patients with APL.
In the right circumstances, APL is a curable disease. Potential cure is an opportunity that should be available to all afflicted individuals.
Disclosures
No conflicts of interest to disclose.
References
1.Hillestad LK. Acute promyelocytic leukemia. Acta Med Scand. 1957;159:189-194.
2. Platzbecker U, Avvisati G, Cicconi L, et al. Improved outcomes with retinoic acid and arsenic trioxide compared with retinoic acid and chemotherapy in non-high-risk acute promyelocytic leukemia: final
results of the randomized Italian-German APL0406 trial. J Cin Oncol.
2017;35(6):605-612.
3.Iland HJ, Collins M, Bradstock K, et al. Use of arsenic trioxide in
remission induction and consolidation therapy for acute promyelo- cytic leukaemia in the Australasian Leukaemia and Lymphoma Group (ALLG) APML4 study: a non-randomised phase 2 trial. Lancet Hematol. 2015;2(9):e357-366.
4. Lehmann S, Deneberg S, Antunovic P, et al. Early death rates remain high in high-risk APL: update from the Swedish Acute Leukemia Registry 1997-2013. Leukemia. 2017;31(6):1457-1459.
5. Park JH, Qiao B, Panageas KS, et al. Early death rate in acute promye- locytic leukemia remains high despite all-trans retinoic acid. Blood. 2011;118(5):1248-1254.
6. McClellan JS, Kohrt HE, Coutre S, et al. Treatment advances have not improved the early death rate in acute promyelocytic leukemia. Haematologica. 2012;97(1):133-136.
7. Altman JK, Rademaker A, Cull E, et al. Administration of ATRA to newly diagnosed patients with acute promyelocytic leukemia is delayed contributing to early hemorrhagic death. Leuk Res. 2013;37(9):1004-1009.
8. Breccia M, Latagliata R, Cannella L, Minotti C, Meloni G, Lo-Coco F. Early hemorrhagic death before starting therapy in acute promyelo- cytic leukemia: association with high WBC count, late diagnosis and delayed treatment initiation. Haematologica. 2010;95(5):853-854.
9. Rahmé R, Thomas X, Recher C, et al. Early death in acute promye- locytic leukemia (APL) in French centers: a multicenter study in 399 patients. Leukemia. 2014;28(12):2422-2424.
10. Rashidi A, Goudar RK, Sayedian F, et al. All-trans retinoic acid and early mortality in acute promyelocytic leukemia. Leuk Res. 2013;37(10):1391-1392.
11. Rashidi A, Riley M, Goldin TA, et al. Delay in the administration of all-trans retinoic acid and its effects on early mortality in acute promyelocytic leukemia: final results of a multicentric study in the United States. Leuk Res. 2014;38(9):1036-1040.
12.Abrahão R, Ribeiro RC, Medeiros BC, Keogh RH, Keegan TH. Cancer disparities in early death and survival in children, adoles- cents, and young adults with acute promyelocytic leukemia in California. Cancer. 2015;121(22):3990-3997.
13. Tallman MS, Manji GA. Don't just stand there, do something: strate- gies for the prevention of early death in acute promyelocytic leukemia: a commentary. Blood Cells Mol Dis. 2011;46(2):173-174.
14.Jillella AP, Arellano ML, Gaddh M, et al. Comanagement strategy between academic institutions and community practices to reduce induction mortality in acute promyelocytic leukemia. JCO Oncol Pract. 2021;17(4):e497-e505.
15. Abrahão R, Ribeiro RC, Malogolowkin MH, Wun T, Keegan THM. Early mortality and survival improvements for adolescents and young adults with acute promyelocytic leukemia in California: an updated analysis. Haematologica. 2022;107(3):733-736.
haematologica | 2022; 107(3)
571


































































































   13   14   15   16   17