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Letters to the Editor
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Figure 2. Cell of origin by NanoString. (A) Responders including duration of response. (B) Best overall response in the 15 patients who had evaluable samples available for NanoString subtyping. All enrolled patients (n=21) had local non–germinal center B-cell (GCB) immunohistochemistry cell-of-origin testing. Archival tumor samples were submitted for central gene sequencing analysis (n=15) using the Lymphoma Subtyping Test (LST) by NanoString platform (Covance Genomics Labs). aCensored. ASCT: autologous stem cell transplantation; BEAM: BiCNU (carmustine), etoposide, Ara-C (cytarabine), and melphalan; CHOP: cyclophosphamide, doxorubicin, vincristine, and prednisolone; CR: complete response; GCB: germinal center B-cell; HSCT: hematopoietic stem cell transplanta- tion; LPS: linear predictor score; PD: progressive disease; PFS: progression-free survival; PR: partial response; R: rituximab; R/R: relapsed/refractory; R-CHOP: cyclophosphamide, doxorubicin, vincristine, and prednisolone + rituximab; R-ESHAP: rituximab, etoposide, solu-medrone, high-dose cytarabine, and cisplatin; RGDB: cisplatin, dexamethasone, gemcitabine and rituximab; RICE: rituximab, ifosfamide, carboplatin, and etoposide; SD: stable disease.
baseline characteristics are shown in the Online Supplementary Table S1. Median age was 64 years (range, 32–84), 48% were male, 71% were white, 67% had an ECOG PS of 1, 57% had Ann Arbor stage IV disease at baseline, and 24% had had prior autologous stem cell transplantation. Median number of prior systemic regi- mens was 3 (range, 1–5), and 81% had received prior R- CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisolone + rituximab). As of the data cutoff date of
30 October 2017, 95% (20 of 21) discontinued the study, 81% (17 of 21) due to disease progression, 9.5% (two of 21) due to AE listed as grade 5 (one respiratory failure with grade 4 pneumonia and lower respiratory Staphylococcus aureus infection not related to treatment, and one with leptomeningeal involvement of DLBCL), and 4.8% (one of 21) to pursue an alternative cancer ther- apy (stem cell transplant) while in CR. There were eight deaths, none considered related to acalabrutinib. One
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