Page 57 - 2021_06-Haematologica-web

Redefinition of HBZ localization in ATL
Jacobson S, Accolla RS. HTLV-1 HBZ protein resides exclusively in the cytoplasm of infected cells in asymptomatic carriers and HAM/TSP patients. Front Microbiol. 2019;10:819.
27.Baratella M, Forlani G, Raval GU, et al. Cytoplasmic localization of HTLV-1 HBZ protein: a biomarker of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). PLoS Negl Trop Dis. 2017;11(1):e0005285.
28. Baratella M, Forlani G, Accolla RS. HTLV-1 HBZ viral protein: a key player in HTLV-1 mediated diseases. Front Microbiol. 2017;8:2615.
29. Raval GU, Bidoia C, Forlani G, Tosi G, Gessain A, Accolla RS. Localization, quan- tification and interaction with host factors of endogenous HTLV-1 HBZ protein in infect- ed cells and ATL. Retrovirology. 2015;12:59.
30. Hivin P, Frédéric M, Arpin-André C, et al. Nuclear localization of HTLV-I bZIP factor (HBZ) is mediated by three distinct motifs. J Cell Sci. 2005;118(7):1355-1362.
31. Hivin P, Basbous J, Raymond F, et al. The HBZ-SP1 isoform of human T-cell leukemia virus type I represses JunB activity by sequestration into nuclear bodies. Retrovirology. 2007;4:14.
32. Tosi G, Forlani G, Andresen V, et al. Major histocompatibility complex class II transacti- vator CIITA is a viral restriction factor that targets human T-cell lymphotropic virus type 1 Tax-1 function and inhibits viral repli- cation. J Virol. 2011;85(20):10719-10729.
33. Forlani G, Abdallah R, Accolla RS, Tosi G. The major histocompatibility complex class II transactivator CIITA inhibits the persist- ent activation of NF-kB by the human T cell
lymphotropic virus type 1 Tax-1 oncopro-
tein. J Virol. 2016;90(7):3708-3721.
34. Shirono K, Hattori T, Matsuoka M, Matsushita S, Asou N, Takatsuki K. Adult T cell leukemia cell lines that originated from primary leukemic clones also had a defect of expression of CD3-T cell receptor complex.
Leukemia. 1988;2(11):728-733.
35. Suzushima H, Asou N, Hattori T, Takatsuki
K. Adult T-cell leukemia derived from S100 beta positive double-negative (CD4- CD8-) T cells. Leuk Lymphoma. 1994;13(3-4):257-262.
36. Artesi M, Marçais A, Durkin K, et al. Monitoring molecular response in adult T- cell leukemia by high-throughput sequenc- ing analysis of HTLV-1 clonality. Leukemia. 2017;31(11):2532-2535.
37.Cavanagh MH, Landry S, Audet B, et al. HTLV-I antisense transcripts initiating in the 3'LTR are alternatively spliced and polyadenylated. Retrovirology. 2006;3:15.
38. Murata K, Hayashibara T, Sugahara K, et al. A novel alternative splicing isoform of human T-cell leukemia virus type 1 bZIP fac- tor (HBZ-SI) targets distinct subnuclear localization. J Virol. 2006;80(5):2495-2505.
39. Ossareh-Nazari B, Bachelerie F, Dargemont C. Evidence for a role of CRM1 in signal- mediated nuclear protein export. Science. 1997;278(5335):141-144.
40. Alefantis T, Flaig KE, Wigdahl B, Jain P. Interaction of HTLV-1 Tax protein with cal- reticulin: implications for Tax nuclear export and secretion. Biomed Pharmacother. 2007;61(4):194-200.
41. Zhao T, Yasunaga J, Satou Y, et al. Human T- cell leukemia virus type 1 bZIP factor selec- tively suppresses the classical pathway of NF-kappaB. Blood. 2009;113(12):2755-2764.
42. Zhi H, Yang L, Kuo YL, Ho YK, Shih HM, Giam CZ. NF-kB hyper-activation by HTLV- 1 tax induces cellular senescence, but can be alleviated by the viral anti-sense protein HBZ. PLoS Pathog. 2011;7(4):e1002025.
43. Yamagishi M, Fujikawa D, Watanabe T, Uchimaru K. HTLV-1-mediated epigenetic pathway to adult T-cell leukemia–lym- phoma. Front Microbiol. 2018;9:1686.
44. Ma G, Yasunaga J-I, Matsuoka M. Multifaceted functions and roles of HBZ in HTLV-1 pathogenesis. Retrovirology. 2016;13:16.
45. Giam C-Z, Semmes OJ. HTLV-1 Infection and adult T-cell leukemia/lymphoma - a tale of two proteins: Tax and HBZ. Viruses. 2016;8(6):161.
46. Matsuoka M, Mesnard J-M. HTLV-1 bZIP factor: the key viral gene for pathogenesis. Retrovirology. 2020;17(1):2.
47. Bazarbachi A, Suarez F, Fields P, Hermine O. How I treat adult T-cell leukemia/lym- phoma. Blood. 2011;118(7):1736-1745.
48. Kinosada H, Yasunaga J-I, Shimura K, et al. HTLV-1 bZIP factor enhances T-cell prolifer- ation by impeding the suppressive signaling of co-inhibitory receptors. PLoS Pathog. 2017;13(1):e1006120.
49. Mahgoub M, Yasunaga J-I, Iwami S, et al. Sporadic on/off switching of HTLV-1 Tax expression is crucial to maintain the whole population of virus-induced leukemic cells. Proc Natl Acad Sci U S A. 2018;115(6): e1269-e1278.
50. Billman MR, Rueda D, Bangham CRM. Single-cell heterogeneity and cell-cycle-relat- ed viral gene bursts in the human leukaemia virus HTLV-1. Wellcome Open Res. 2017; 2:87.
haematologica | 2021; 106(8)
2085