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CAR promotes hematopoietic regeneration
stress.10,29,47,48 Our study suggests that the coupling of Notch with CAR enables a checked cell fate of HSC with increased cell cycling but not over-differentiation. Overall the mechanism facilitates the entry of quiescent HSC into the cell cycle with maintenance of stemness. Our continu- ous study in this subject may lead to development of novel strategies for promotion of stem cell regeneration.
Contributions
GW contributed to design, experimental performance, inter- pretation, and writing; CCZ contributed to design and writing.
Acknowledgments
We thank the NIH (1R01CA172268), the Leukemia & Lymphoma Society (1024-14), the March of Dimes Foundation (1-FY14-201), the Cancer Prevention and Research Institute of Texas (RP180435), and the Robert A. Welch Foundation (I- 1834) for generous support.
Disclosures
No conflicts of interest to disclose.
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