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Letters to the Editor
modulating SCD end-organ damage, could have tremen- dous relevance in low-resource settings worldwide, where the burden of SCD is greatest. However, adequately powered studies would need to be conducted to rigorously evaluate the safety of this approach and closely assess the risk of CDI.
Philip Lee,1* Arpan A. Sinha,2* Vijaya L. Soma,1,3
Carlos Cruz,1 Tao Wang,4 Olga Aroniadis,5,6
Betsy C. Herold,1,3 Paul S. Frenette,6 David L. Goldman1,3# and Deepa Manwani1,3#
1Department of Pediatrics, The Children’s Hospital at Montefiore, Bronx, NY; 2Jimmy Everest Section of Pediatric Hematology/Oncology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK; 3Department of Pediatrics, The Albert Einstein College of Medicine, Bronx, NY; 4Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY;
5Department of Medicine, Montefiore Medical Center, Bronx,
NY and 6Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA
*PL and AAS contributed equally as co-first authors. #DLG and DM contributed equally as co-senior authors. Correspondence:
DEEPA MANWANI - dmanwani@montefiore.org doi:10.3324/haematol.2019.244582
Received: December 11, 2019.
Accepted: September 10, 2020.
Pre-published: September 14, 2020.
Disclosures: no conflicts of interest to disclose.
Contributions: PL and AS are the main manuscript authors; DLG, DM, PL, AS and VLS designed the study, reviewed the data, and did the majority of manuscript writing; OA performed related research and provided critical manuscript review that led to a redesign; TW provided statistical support; CC performed research and data analysis; BCH and PSF contributed to the study design and manuscript review.
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