Page 122 - 2021_05-Haematologica-web

D. Stroopinsky et al.
Dimensionality reduction for visualizing
single-cell data using UMAP. Nat Biotechnol. 2018 Dec 3. doi: 10.1038/nbt.4314. [Online ahead of print].
24. Satija R, Farrell JA, Gennert D, et al. Spatial reconstruction of single-cell gene expression data. Nat Biotechnol. 2015;33(5):495-502.
25. Brahmer JR, Tykodi SS, Chow LQM, et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med. 2012;366(26):2455-2465.
26.StahlM,GoldbergAD.Immunecheckpoint inhibitors in acute myeloid leukemia: novel combinations and therapeutic targets. Curr Oncol Rep. 2019;21(4):37.
27. Hale DF, Vreeland TJ, Peoples GE. Arming
the immune system through vaccination to prevent cancer recurrence. Am Soc Clin Oncol Educ Book. 2016;(36):e159-e167.
28. Zuazo M, Arasanz H, Fernández-Hinojal G, et al. Functional systemic CD4 immunity is required for clinical responses to PD-L1/PD- 1 blockade therapy. EMBO Mol Med. 2019;11(7):e10293.
differentiation. Curr Opin Immunol. 2010;
22(5):655-661.
32. Thompson CB, Lindsten T, Ledbetter JA, et
al. CD28 activation pathway regulates the production of multiple T-cell-derived lym- phokines/cytokines. Proc Natl Acad Sci U S A. 1989;86(4):1333-1337.
33. Dong C, Juedes AE, Temann UA, et al. ICOS co-stimulatory receptor is essential for T-cell activation and function. Nature. 2001;409 (6816):97-101.
34.Sehgal A, Whiteside TL, Boyiadzis M. Programmed death-1 checkpoint blockade in acute myeloid leukemia. Expert Opin Biol Ther. 2015;15(8):1191-1203.
29. Araki K, Turner AP, Shaffer VO, et al. mTOR regulates memory CD8 T-cell differentia- tion. Nature. 2009;460(7251):108-112.
30.LiuT,ZhangL,JooD,SunS-C.NF-κBsig- naling in inflammation. Signal Transduct Target Ther. 2017;2:17023.
31. Peter C, Waldmann H, Cobbold SP. mTOR signalling and metabolic regulation of T cell
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