Page 168 - 2021_02-Haematologica-web

C. Fugazza et al.
10. Lin FJ, Qin J, Tang K, Tsai SY, Tsai MJ. Coup
d’etat: an orphan takes control. Endocr Rev.
2011;32(3):404-421.
11. Filipe A, Li Q, Deveaux S, et al. Regulation
of embryonic/fetal globin genes by nuclear hormone receptors: a novel perspective on hemoglobin switching. EMBO J. 1999;18(3): 687-697.
12. Cui S, Tanabe O, Sierant M, et al. Compound loss of function of nuclear recep- tors Tr2 and Tr4 leads to induction of murine embryonic β-type globin genes. Blood. 2015;125(9):1477-1487.
13. Liberati C, Ronchi A, Lievens P, Ottolenghi S, Mantovani R. NF-Y organizes the gamma-globin CCAAT boxes region. J Biol Chem. 1998;273(27):16880-16889.
14. Ronchi AE, Bottardi S, Mazzucchelli C, Ottolenghi S, Santoro C. Differential bind- ing of the NFE3 and CP1/NFY transcription factors to the human gamma- and epsilon- globin CCAAT boxes. J Biol Chem. 1995;270(37):21934-21941.
15. Liberati C, Cera MR, Secco P, et al. Cooperation and competition between the binding of COUP-TFII and NF-Y on human epsilon- and gamma-globin gene promoters. J Biol Chem. 2001;276(45):41700-41709.
16. Cui S, Kolodziej KE, Obara N, et al. Nuclear receptors TR2 and TR4 recruit multiple epi- genetic transcriptional corepressors that associate specifically with the embryonic β- type globin promoters in differentiated adult erythroid cells. Mol Cell Biol. 2011;31(16): 3298-3311.
17. Zhu X, Wang Y, Pi W, Liu H, Wickrema A, Tuan D. NF-Y recruits both transcription activator and repressor to modulate tissue- and developmental stage-specific expression of human γ-globin gene. PLoS One. 2012;7(10):e47175.
18. Durlak M, Fugazza C, Elangovan S, et al. A novel high-content immunofluorescence assay as a tool to identify at the single cell level γ-globin inducing compounds. PLoS One. 2015;10(10):e0141083.
19. von Lindern M, Deiner EM, Dolznig H, et al. Leukemic transformation of normal murine erythroid progenitors: v- and c-ErbB act through signaling pathways activated by the EpoR and c-Kit in stress erythropoiesis. Oncogene. 2001;20(28):3651-3664.
20. Migliaccio G, Di Pietro R, Di Giacomo V, et al. In vitro mass production of human ery- throid cells from the blood of normal donors and thalassemic patients. Blood Cells Mol Dis. 2002;28(2):169-180.
21. Schreiber E, Matthias P, Muller MM, Schaffner W. Rapid detection of octamer binding proteins with 'mini-extracts', pre-
pared from a small number of cells. Nucleic
Acids Res. 1989;17(15):6419.
22. Afgan E, Baker D, van den Beek M, et al.
The Galaxy platform for accessible, repro- ducible and collaborative biomedical analy- ses: 2016 update. Nucleic Acids Res. 2016;44(W1):W3-W10.
23. Li H, Durbin R. Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics. 2009;25(14):1754-1760.
24. Heinz S, Benner C, Spann N, et al. Simple combinations of lineage-determining tran- scription factors prime cis-regulatory ele- ments required for macrophage and B cell identities. Mol Cell. 2010;38(4):576-589.
25. Ramirez F, Dundar F, Diehl S, Gruning BA, Manke T. deepTools: a flexible platform for exploring deep-sequencing data. Nucleic Acids Res. 2014;42(Web Server issue):W187- 191.
26. Quinlan AR, Hall IM. BEDTools: a flexible suite of utilities for comparing genomic fea- tures. Bioinformatics. 2010;26(6):841-842.
27. Machanick P, Bailey TL. MEME-ChIP: motif analysis of large DNA datasets. Bioinformatics. 2011;27(12):1696-1697.
28. Palstra RJ, Tolhuis B, Splinter E, Nijmeijer R, Grosveld F, de Laat W. The beta-globin nuclear compartment in development and erythroid differentiation. Nat Genet. 2003;35(2):190-194.
29. Xu J, Sankaran VG, Ni M, et al. Transcriptional silencing of γ-globin by BCL11A involves long-range interactions and cooperation with SOX6. Genes Dev. 2010;24(8):783-798.
30. Patrinos GP, de Krom M, de Boer E, et al. Multiple interactions between regulatory regions are required to stabilize an active chromatin hub. Genes Dev. 2004;18(12): 1495-1509.
31.Cao A, Galanello R, Furbetta M, et al. Thalassaemia types and their incidence in Sardinia. J Med Genet. 1978;15(6):443-447.
32. Baserga SJ, Benz EJ, Jr. Beta-globin nonsense mutation: deficient accumulation of mRNA occurs despite normal cytoplasmic stability. Proc Natl Acad Sci U S A. 1992;89(7):2935- 2939.
33. Erdos E, Balint BL. COUP-TFII is a modula- tor of cell-type-specific genetic programs based on genomic localization maps. J Biotechnol. 2019;301:11-17.
34. Mathelier A, Fornes O, Arenillas DJ, et al. JASPAR 2016: a major expansion and update of the open-access database of transcription factor binding profiles. Nucleic Acids Res. 2016;44(D1):D110-115.
35. Higgs DR, Engel JD, Stamatoyannopoulos G. Thalassaemia. Lancet. 2012;379(9813):
373-383.
36. Suzuki M, Yamamoto M, Engel JD. Fetal
globin gene repressors as drug targets for molecular therapies to treat the β-glo- binopathies. Mol Cell Biol. 2014;34(19): 3560-3569.
37. Ottolenghi S, Nicolis S, Bertini C, Ronchi A, Crotta S, Giglioni B. Regulation of gamma- globin expression in hereditary persistence of fetal hemoglobin. Ann N Y Acad Sci. 1990;612:191-195.
38. Ronchi A, Berry M, Raguz S, et al. Role of the duplicated CCAAT box region in gamma-globin gene regulation and heredi- tary persistence of fetal haemoglobin. EMBO J. 1996;15(1):143-149.
39. Wijgerde M, Grosveld F, Fraser P. Transcription complex stability and chro- matin dynamics in vivo. Nature. 1995;377 (6546):209-213.
40. Liu N, Hargreaves VV, Zhu Q, et al. Direct promoter repression by BCL11A controls the fetal to adult hemoglobin switch. Cell. 2018;173(2):430-442.
41. Tanabe O, McPhee D, Kobayashi S, et al. Embryonic and fetal beta-globin gene repres- sion by the orphan nuclear receptors, TR2 and TR4. EMBO J. 2007;26(9):2295-2306.
42. Jonk LJ, de Jonge ME, Vervaart JM, Wissink S, Kruijer W. Isolation and developmental expression of retinoic-acid-induced genes. Dev Biol. 1994;161(2):604-614.
43. Qiu Y, Krishnan V, Pereira FA, Tsai SY, Tsai MJ. Chicken ovalbumin upstream promot- er-transcription factors and their regulation. J Steroid Biochem Mol Biol. 1996;56(1-6 Spec No):81-85.
44.
Soosaar A, Neuman K, Nornes HO, Neuman T. Cell type specific regulation of COUP-TF II promoter activity. FEBS Lett. 1996;391(1-2):95-100.
45.Krishnan V, Elberg G, Tsai MJ, Tsai SY. Identification of a novel sonic hedgehog response element in the chicken ovalbumin upstream promoter-transcription factor II promoter. Mol Endocrinol. 1997;11(10): 1458-1466.
46. Petit FG, Salas R, Tsai MJ, Tsai SY. The reg- ulation of COUP-TFII gene expression by Ets-1 is enhanced by the steroid receptor co- activators. Mech Ageing Dev. 2004;125(10- 11):719-732.
47. Kruse SW, Suino-Powell K, Zhou XE, et al. Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor. PLoS Biol. 2008;6(9):e227.
48. Yoon K, Chen CC, Orr AA, Barreto PN, Tamamis P, Safe S. Activation of COUP-TFI by a novel diindolylmethane derivative. Cells. 2019;8(3):220.
482
haematologica | 2021; 106(2)