Page 183 - Haematologica Atlas of Hematologic Cytology

CHAPTER 18 - - - Mature T- and NK-cell neoplasms
Figure 11 naplas c c c large cell lymphoma ( L L L L) L L L nega ve Bu y y coat smear showing very large cells with abundant cytoplasm and prominent nucleoli They were strongly posi ve ve for CD30 and and expressed the T-cell an an an gens CD2 CD3 CD3 and and CD4 with ALK protein undetectable ALK-nega ve ALCL now included as as as as as as an en ty in in the group of mature T-cell neoplasms
is characterized by older pa ent age and a a a a a a a a a more aggressive clinical course than ALK-posi ve ve ALCL Figure 1 naplas c c c large cell lymphoma ( L L L L) L L L nega ve The same bu y y coat smear as as in Figure 11 reveals large pleomorphic neoplas c c c c cells with irregular nuclear outlines In ALK-nega ve ALCL cells are larger and more pleomorphic than in in ALK-posi - - - ve ALCL Mul nucleated cells cells and cells cells with eccentric horseshoe-shaped or or kidney-sha- ped nuclei are some mes observed 170