Page 175 - Haematologica-5

Fibrinogen, GPVI and platelet activation
5. Nieswandt B, Watson SP. Platelet-collagen interaction: is GPVI the central receptor? Blood. 2003;102(2):449-461.
6. Inoue O, Suzuki-Inoue K, McCarty OJ, et al. Laminin stimulates spreading of platelets through integrin alpha6beta1-dependent activation of GPVI. Blood. 2006;107(4):1405- 1412.
7. Mammadova-bach E, Ollivier V, Loyau S, et al. Platelet glycoprotein VI binds to polymer- ized fibrin and promotes thrombin genera- tion. Blood. 2016;126(5):683-692.
8. Alshehri OM, Hughes CE, Montague S, et al. Fibrin activates GPVI in human and mouse platelets. Blood. 2015;126(13):1601- 1608.
9. Riba R, Hughes CE, Graham A, Watson SP, Naseem KM. Globular adiponectin induces platelet activation through the collagen receptor GPVI-Fc receptor chain complex. J Thromb Haemost. 2008;6(6):1012-1020.
10. Seizer P, Borst O, Langer HF, et al. EMM- PRIN (CD147) is a novel receptor for platelet GPVI and mediates platelet rolling via GPVI- EMMPRIN interaction. Thromb Haemost. 2009;101(4):682-686.
11. Schaff M, Tang CJ, Maurer E, et al. Integrin 61 is the main receptor for vascular laminins and plays a role in platelet adhe- sion, activation, and arterial thrombosis.
Circulation. 2013;128(5):541-552.
12. Boulaftali Y, Hess PR, Getz TM, et al. Platelet ITAM signaling is critical for vascu- lar integrity in inflammation. J Clin Invest.
2013;123(2):908-916.
13. Kuijpers MJE, Gilio K, Reitsma S, et al.
Complementary roles of platelets and coag- ulation in thrombus formation on plaques acutely ruptured by targeted ultrasound treatment: a novel intravital model. J Thromb Haemost. 2009;7(1):152-161.
14. Hechler B, Gachet C. Comparison of two murine models of thrombosis induced by atherosclerotic plaque injury. Thromb Haemost. 2011;105 (Suppl):S3-12.
15. Bender M, Hagedorn I, Nieswandt B. Genetic and antibody-induced glycoprotein VI deficiency equally protects mice from mechanically and FeCl3-induced thrombo- sis. J Thromb Haemost. 2011;9(7):1423- 1426.
16. Nieswandt B, Schulte V, Bergmeier W, et al. Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice. J Exp Med. 2001;193(4):459-469.
17. Matus V, Valenzuela G, Sáez CG, et al. An adenine insertion in exon 6 of human GP6 generates a truncated protein associated with a bleeding disorder in four Chilean families. J Thromb Haemost. 2013;11(9):1751-1759.
18. Dumont B, Lasne D, Rothschild C, et al. Absence of collagen-induced platelet activa- tion caused by compound heterozygous GPVI mutations. Blood. 2009;114(9):1900- 1903.
19. Hermans C, Wittevrongel C, Thys C, Smethurst PA, Van Geet C, Freson K. A com- pound heterozygous mutation in glycopro- tein VI in a patient with a bleeding disorder. J Thromb Haemost. 2009;7(8):1356-1363.
20. Zahid M, Mangin P, Loyau S, et al. The future of glycoprotein VI as an antithrom- botic target. J Thromb Haemost. 2012;10(12):2418-2427.
21. Bennett JS, Berger BW, Billings PC. The structure and function of platelet integrins. J Thromb Haemost. 2009;7(Suppl 1):200-205.
22. Obergfell A, Judd BA, Del Pozo MA, Schwartz MA, Koretzky GA, Shattil SJ. The molecular adapter SLP-76 relays signals from platelet integrin aIIbβ3 to the actin cytoskeleton. J Biol Chem. 2001;276(8): 5916-5923.
23. Goncalves I, Hughan SC, Schoenwaelder SM, Yap CL, Yuan Y, Jackson SP. Integrin aIIbβ3-dependent calcium signals regulate platelet-fibrinogen interactions under flow: Involvement of phospholipase Cγ2. J Biol Chem. 2003;278(37):34812-34822.
24. Wonerow P, Pearce AC, Vaux DJ, Watson SP. A critical role for phospholipase Cγ2 in aIIbβ3-mediated platelet spreading. J Biol Chem. 2003;278(39):37520-37529.
25. Watson SP, Auger JM, McCarty OJ, Pearce AC. GPVI and integrin aIIbβ3 signaling in platelets. J Thromb Haemost. 2005;3(8): 1752-1762.
26. Boylan B, Gao C, Rathore V, Gill JC, Newman DK, Newman PJ. Identification of FcgammaRIIa as the ITAM-bearing receptor mediating alphaIIbbeta3 outside-in integrin signaling in human platelets. Blood. 2008;112(7):2780-2786.
27. Hughes CE, Finney BA, Koentgen F, Lowe KL, Watson SP. The N-terminal SH2 domain of Syk is required for (hem) ITAM, but not integrin, signaling in mouse platelets. Blood. 2015;125(1):144-155.
28. Zhi H, Rauova L, Hayes V, et al. Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo. Thromb Haemost. 2013;121(10): 1858-1867.
29. Law DA, DeGuzman FR, Heiser P, Ministri-Madrid K, Killeen N, Phillips DR. Integrin cytoplasmic tyrosine motif is required for outside-in aIIbβ3 signalling and platelet function. Nature. 1999;401 (6755):808-811.
30. Onselaer M-B, Hardy AT, Wilson C, et al. Fibrin and D-dimer bind to monomeric GPVI. Blood Adv. 2017; 1(19):1495-1504.
31. Kato K, Kanaji T, Russell S, et al. The contri- bution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrat- ed by targeted gene deletion. Blood. 2003;102(5):1701-1707.
32. Mangin PH, Tang C, Bourdon C, et al. A humanized glycoprotein VI (GPVI) mouse model to assess the antithrombotic effica- cies of anti-GPVI agents. J Pharmacol Exp Ther. 2012;341(1):156-163.
33. Jandrot-Perrus M, Busfield S, Lagrue AH, et al. Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily. Blood. 2000;96(5):1798-1807.
34. Perrault C, Moog S, Rubinstein E, et al. A novel monoclonal antibody against the extracellular domain of GPIbbeta modulates vWF mediated platelet adhesion. Thromb Haemost. 2001;86(5):1238-1248.
35. Lecut C, Feeney LA, Kingsbury G, et al. Human platelet glycoprotein VI function is antagonized by monoclonal antibody- derived Fab fragments. J Thromb Haemost. 2003;1(12):2653-2662.
36. Lebozec K, Jandrot-Perrus M, Avenard G, Favre-Bulle O, Billiald P. Design, develop- ment and characterization of ACT017, a humanized Fab that blocks platelet’s glyco- protein VI function without causing bleed- ing risks. MAbs. 2017:9(6):945-958.
37. Hughes CE, Sinha U, Pandey A, Eble JA,
O’Callaghan CA, Watson SP. Critical role for an acidic amino acid region in platelet signal- ing by the HemITAM (hemi-immunorecep- tor tyrosine-based activation motif) contain- ing receptor CLEC-2 (C-type lectin receptor- 2). J Biol Chem. 2013;288(7):5127-5135.
38. Hui KY, Haber E, Matsueda GP,Monoclonal antibodies to a synthetic fibrin-like peptide bind to human fibrin but not fibrinogen. Science 1983,222(4628):1129-1132.
39. Cazenave J-P, Ohlmann P, Cassel D, Eckly A, Hechler B, Gachet C. Preparation of washed platelet suspensions from human and rodent blood. Methods Mol Biol. 2004;272:13-28.
40. Schaff M, Receveur N, Bourdon C, et al. Novel function of tenascin-C, a matrix pro- tein relevant to atherosclerosis, in platelet recruitment and activation under flow. Arterioscler Thromb Vasc Biol. 2011;31(1): 117-124.
41. Haimovich B, Lipfert L, Brugge JS, Shattil SJ. Tyrosine phosphorylation and cytoskeletal reorganization in platelets are triggered by interaction of integrin receptors with their immobilized ligands. J Biol Chem. 1993;268(21):15868-15877.
42. Poulter NS, Pollitt AY, Owen DM, et al. Clustering of glycoprotein VI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets. J Thromb Haemost. 2017;15(3):549-564.
43. Evans R, Patzak I, Svensson L, et al. Integrins in immunity. J Cell Sci. 2009;122(2):215-225. 44. Miura Y, Takahashi T, Jung SM, Moroi M. Analysis of the interaction of platelet colla- gen receptor glycoprotein VI (GPVI) with collagen: a dimeric form of GPVI, but not the monomeric form, shows affinity to fibrous collagen. J Biol Chem. 2002;277
(48):46197-46204.
45. Loyau S, Dumont B, Ollivier V, et al. Platelet
glycoprotein VI dimerization, an active process inducing receptor competence, is an indicator of platelet reactivity. Arterioscler Thromb Vasc Biol. 2012;32(3):778-785.
46. Aslan JE, Phillips KG, Healy LD, et al. Histone deacetylase 6-mediated deacetyla- tion of a-tubulin coordinates cytoskeletal and signaling events during platelet activa- tion. AJP Cell Physiol. 2013;305(12):C1211- C1213.
47. Kulkarni S, Dopheide SM, Yap CL, et al. A revised model of platelet aggregation. J Clin Invest. 2000;105(6):783-791.
48. Yang H, Reheman A, Chen P, Zhu G. Fibrinogen and von Willebrand factor-inde- pendent platelet aggregation in vitro and in vivo. J Thromb Haemost. 2006;4(10):2230- 2237.
49. Reheman A, Yang H, Zhu G, et al. Plasma fibronectin depletion enhances platelet aggregation and thrombus formation in mice lacking fibrinogen and von Willebrand factor plasma fibronectin depletion enhances platelet aggregation and thrombus formation in mice lacking fibrinogen and von Willebrand factor. 2012;113(8):1809- 1817.
50. Cho J, Mosher DF. Impact of fibronectin assembly on platelet thrombus formation in response to type I collagen and von Willebrand factor. Blood. 2006;108(7):2229- 2236.
51. Maurer E, Schaff M, Receveur N, Bourdon C, Mercier L, Nieswandt B. Fibrillar cellular fibronectin supports efficient platelet func- tion and procoagulant activity. Thromb Haemost. 2015;114(6):1175-1188.
haematologica | 2018; 103(5)
907