Page 100 - Haematologica-April 2018
P. 100

P.B. Sinclair et al.
significantly reduces the risk of relapse
among children and adolescents with acute lymphoblastic leukemia and intrachromo- somal amplification of chromosome 21: a comparison of the MRC ALL97/99 and UKALL2003 trials. J Clin Oncol. 2013;31(27):3389-3396.
18. Heerema NA, Carroll AJ, Devidas M, et al. Intrachromosomal amplification of chromo- some 21 is associated with inferior out- comes in children with acute lymphoblastic leukemia treated in contemporary standard- risk Children's Oncology Group studies: a report from the Children's Oncology Group. J Clin Oncol. 2013;31(27):3397-3402.
19. Harrison CJ, Haas O, Harbott J, et al. Detection of prognostically relevant genetic abnormalities in childhood B-cell precursor acute lymphoblastic leukaemia: recom- mendations from the Biology and Diagnosis Committee of the International Berlin-Frankfurt-Munster study group. Br J Haematol. 2010;151(2):132-142.
20. Schwab C, Harrison CJ. Acute lymphoblas- tic leukaemia. Methods Mol Biol. 2011;730:99-117.
21. Schwab CJ, Chilton L, Morrison H, et al. Genes commonly deleted in childhood B- cell precursor acute lymphoblastic leukemia: association with cytogenetics and clinical features. Haematologica. 2013;98(7):1081-1088.
22. Bomken S, Buechler L, Rehe K, et al. Lentiviral marking of patient-derived acute lymphoblastic leukaemic cells allows in vivo tracking of disease progression. Leukemia. 2013;27(3):718-721.
23. Travlos GS. Normal structure, function, and histology of the bone marrow. Toxicol Pathol. 2006;34(5):548-565.
24. Elmore S. Apoptosis: a review of pro- grammed cell death. Toxicol Pathol. 2007;35(4):495-516.
25. Russell LJ, Capasso M, Vater I, et al. Deregulated expression of cytokine recep- tor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute
lymphoblastic leukemia. Blood.
2009;114(13):2688-2698.
26. Rauch PJ, Ellegast JM, Widmer CC, et al.
MPL expression on AML blasts predicts peripheral blood neutropenia and thrombo- cytopenia. Blood. 2016;128(18):2253-2257.
27. Notta F, Mullighan CG, Wang JC, et al. Evolution of human BCR-ABL1 lym- phoblastic leukaemia-initiating cells. Nature. 2011;469(7330):362-367.
28. Bardini M, Woll PS, Corral L, et al. Clonal variegation and dynamic competition of leukemia-initiating cells in infant acute lym- phoblastic leukemia with MLL rearrange- ment. Leukemia. 2015;29(1):38-50.
29. Park SY, Gonen M, Kim HJ, Michor F, Polyak K. Cellular and genetic diversity in the progression of in situ human breast car- cinomas to an invasive phenotype. J Clin Invest. 2010;120(2):636-644.
30. Guilherme RS, Meloni VF, Kim CA, et al. Mechanisms of ring chromosome forma- tion, ring instability and clinical conse- quences. BMC Med Genet. 2011;12:171.
31. Clappier E, Gerby B, Sigaux F, et al. Clonal selection in xenografted human T cell acute lymphoblastic leukemia recapitulates gain of malignancy at relapse. J Exp Med. 2011;208(4):653-661.
32. Caye A, Strullu M, Guidez F, et al. Juvenile myelomonocytic leukemia displays muta- tions in components of the RAS pathway and the PRC2 network. Nat Genet. 2015;47(11):1334-1340.
33. Cutts BA, Sjogren AK, Andersson KM, et al. Nf1 deficiency cooperates with oncogenic K-RAS to induce acute myeloid leukemia in mice. Blood. 2009;114(17):3629-3632.
34. Moriyama T, Metzger ML, Wu G, et al. Germline genetic variation in ETV6 and risk of childhood acute lymphoblastic leukaemia: a systematic genetic study. Lancet Oncol. 2015;16(16):1659-1666.
35. Perez-Garcia A, Ambesi-Impiombato A, Hadler M, et al. Genetic loss of SH2B3 in acute lymphoblastic leukemia. Blood. 2013;122(14):2425-2432.
36. Jumaa H, Bossaller L, Portugal K, et al. Deficiency of the adaptor SLP-65 in pre-B- cell acute lymphoblastic leukaemia. Nature. 2003;423(6938):452-456.
37. Inabe K, Kurosaki T. Tyrosine phosphoryla- tion of B-cell adaptor for phosphoinositide 3-kinase is required for Akt activation in response to CD19 engagement. Blood. 2002;99(2):584-589.
38. Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T. BCAP: the tyrosine kinase sub- strate that connects B cell receptor to phos- phoinositide 3-kinase activation. Immunity. 2000;13(6):817-827.
39. Castello A, Gaya M, Tucholski J, et al. Nck- mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells. Nat Immunol. 2013;14(9):966-975.
40. Okamoto R, Ogawa S, Nowak D, et al. Genomic profiling of adult acute lym- phoblastic leukemia by single nucleotide polymorphism oligonucleotide microarray and comparison to pediatric acute lym- phoblastic leukemia. Haematologica. 2010;95(9):1481-1488.
41. Safavi S, Hansson M, Karlsson K, Biloglav A, Johansson B, Paulsson K. Novel gene tar- gets detected by genomic profiling in a con- secutive series of 126 adults with acute lymphoblastic leukemia. Haematologica. 2015;100(1):55-61.
42. Eswaran J, Sinclair P, Heidenreich O, et al. The pre-B-cell receptor checkpoint in acute lymphoblastic leukaemia. Leukemia. 2015;29(8):1623-1631.
43. Fernandes I, Bastien Y, Wai T, et al. Ligand- dependent nuclear receptor corepressor LCoR functions by histone deacetylase- dependent and -independent mechanisms. Mol Cell. 2003;11(1):139-150.
44. Alekseyenko AA, Gorchakov AA, Kharchenko PV, Kuroda MI. Reciprocal interactions of human C10orf12 and C17orf96 with PRC2 revealed by BioTAP- XL cross-linking and affinity purification. Proc Natl Acad Sci USA. 2014;111(7):2488- 2493.
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